ibuprofen/famotidine (Rx)

Brand and Other Names:Duexis
  • Print

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

ibuprofen/famotidine

tablet

  • 800mg/26.6mg
more...

Rheumatoid Arthritis

Indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease risk of developing upper GI ulcers

1 tablet PO q8hr

Osteoarthritis

Indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease risk of developing upper GI ulcers

1 tablet PO q8hr

Safety and efficacy not established

Rheumatoid Arthritis

Indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease risk of developing upper GI ulcers

1 tablet PO q8hr

Osteoarthritis

Indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease risk of developing upper GI ulcers

1 tablet PO q8hr

Next:

Interactions

Interaction Checker

and ibuprofen/famotidine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 
            Previous
            Next:

            Adverse Effects

            1-10%

            Nausea (6%)

            Dyspepsia (5%)

            Diarrhea (5%)

            Constipation (4%)

            Headache (3%)

            Hypertension (3%)

            Upper abdominal pain (3%)

            Gastroesophageal reflux (2%)

            Vomiting (2%)

            Stomach discomfort (2%)

            Anemia (2%)

            Peripheral edema (2%)

            Previous
            Next:

            Warnings

            Black Box Warnings

            Cardiovascular risk

            • Contains ibuprofen; may increase the risk of serious CV thrombotic events, myocardial infarction, and stroke, which can be fatal; risk may increase with duration of use
            • Patients with CV disease or risk factors may be at greater risk
            • Contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery

            Gastrointestinal risk

            • NSAIDs, including ibuprofen, increase the risk of serious GI adverse reactions including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
            • Reactions can occur at any time without warning symptoms
            • Elderly patients are at greater risk

            Contraindications

            Hypersensitivity

            Pre-existing asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs

            Use during the perioperative period in the setting of CABG surgery

            Starting at 30 weeks gestation, NSAIDs should not be used by pregnant women as premature closure of the ductus arteriosus in the fetus may occur

            Cautions

            Hypertension can occur with NSAID treatment; monitor blood pressure

            Fluid retention and edema can occur with NSAID treatment; use with caution in patients with fluid retention or heart failure

            Antiplatelet effect; active and clinically significant bleeding from any source can occur; discontinue if active bleeding occurs

            Long-term NSAID administration can result in renal papillary necrosis and other renal injury; caution in patients at risk (eg elderly, existing renal impairment, heart failure, liver impairment, coadministration with diuretics or ACE inhibitors)

            Anaphylaxis may occur; especially in asthmatic patients experiencing rhinitis and bronchospasm; discontinue immediately if an anaphylactoid reaction occurs

            Serious/fatal skin reactions may occur and include exfoliative dermatitis, Stevens-Johnson Syndrome, and toxic epidermal necrolysis; discontinue if rash or other signs of local skin reaction occur

            Hepatic injury ranging from transaminase elevations to liver failure can occur; discontinue immediately if abnormal liver tests persist or worsen, if clinical signs and symptoms of liver disease develop, or if systemic manifestations occur

            Previous
            Next:

            Pregnancy & Lactation

            Pregnancy Category: C; D (after 30 weeks gestation)

            Avoid during late stages of pregnancy; NSAIDs are known to cause premature closure of the ductus arteriosus in the fetus

            The Quebec Pregnancy Registry identified 4705 women who had spontaneous abortions by 20 weeks' gestation; each case was matched to 10 control subjects (n=47,050) who had not had spontaneous abortions; exposure to nonaspirin NSAIDs during pregnancy was documented in approximately 7.5% of cases of spontaneous abortions and in approximately 2.6% of controls. (CMAJ, September 6, 2011; DOI:10.1503/cmaj.110454)

            Lactation: Unknown whether distributed in breast milk; caution advised

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next:

            Pharmacology

            Ibuprofen: NSAID; elicits analgesic and antipyretic effects by prostaglandin synthetase inhibition

            Famotidine: H2-receptor antagonist; inhibits gastric acid secretion, thereby lowering gastric pH

            Pharmacokinetics

            Protein Bound: extensive (ibuprofen); 15-20% (famotidine)

            Excretion

            Half-life: 2 hr (ibuprofen); 4 hr (famotidine)

            Renal clearance: 250-450 mL/min (famotidine)

            Urine: Ibuprofen metabolite (45-79%); free or conjugated drug (1-14%); famotidine (65-70% with 30% as unchanged)

            Absorption

            • Peak Plasma Time: 1.9 hr (ibuprofen); 2 hr (famotidine); food delays peak time
            • Peak Plasma Concentration: 45 mcg/mL (ibuprofen); 61 ng/mL (famotidine)
            • AUC: Food reduces AUC by 11-15%
            Previous
            Next:

            Images

            Previous
            Next:

            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous