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triamterene (Rx)Brand and Other Names:Dyrenium

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

capsule

  • 50mg
  • 100mg
more...

Edema

100-300 mg/day PO qDay or divided q12hr

Hypertension

100-300 mg/day PO qDay or divided q12hr

Renal Impairment

CrCl <10 mL: Do not use

Hepatic Impairment

Reduce dose in patients with cirrhosis

Other Information

Monitor serum potassium

See also combo with HCTZ

Dosage Forms & Strengths

capsule

  • 50mg
  • 100mg
more...

Hypertension (Off-label)

Safety & efficacy not established

1-2 mg/kg/day PO divided q12hr 

Maximum dose: 3-4 mg/kg/day PO divided q12hr up to 300 mg/day

Consider lower initial doses

Edema

50-300 mg/day PO qDay or divided q12hr

Hypertension

50-300 mg/day PO qDay or divided q12hr

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Interactions

Interaction Checker

triamterene and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            CHF

            Edema

            Hypotension

            Dizziness

            Fatigue

            HA

            Photosensitivity

            Rash

            Diarrhea

            Nausea

            Vomiting

            Hyperuricemia

            Nephrotoxicity

            Frequency Not Defined

            GI upset

            Thrombocytopenia

            Nephrolithiasis

            Folic acid antagonism

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            Warnings

            Contraindications

            Hypersensitivity to triamterene

            Anuria, severe liver disease, renal failure

            Hyperkalemia

            Concomitant use with K+-sparing diuretic, or K supplementation

            Cautions

            Acid-base imbalance, electrolyte abnormalities, hyperuricemia or gout, liver dz, renal impairment, renal stones

            Breastfeeding

            Interferes with fluorescent assay of quinidine

            Not recommended for pregnancy-induced HTN

            Use during pregnancy may increase risk of cardiovascular defects and oral cleft in child

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Discontinue drug or nursing

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Direct effect on renal distal tubule to inhibit Na+ reabsorption

            Inhibits Na/K-ATPase, decreases Ca++ , Mg++ and hydrogen excretion

            Pharmacokinetics

            Half-Life: 1.5-2.5 hr

            Duration: 7-9 hr

            Onset: Initial effect: 2-4 hr; Max effect: diuresis: several days, HTN: 2-3 months

            Peak Plasma Time: 1.5-3 hr

            Bioavailability: 30-70%

            Protein Bound: 55-67%

            Metabolism: Liver

            Metabolites: hydroxytriamterene sulfate (active)

            Excretion: urine 21%

            Dialyzable: Yes (hemodialysis)

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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