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anidulafungin (Rx)Brand and Other Names:Eraxis

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

powder for injection

  • 50mg
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Candidemia, Candidal Peritonitis, Intra-Abdominal Abscess

Day 1: 200 mg IV infusion, THEN

Day 2 Onwards: 100 mg/day IV

Generally continue 14 days after last positive culture

Esophageal Candidiasis

Day 1: 100 mg IV infusion, THEN

Day 2 Onwards: 50 mg/day IV

Minimum 14 day treatment, at least 7 days following resolution of symptoms

Safety and efficacy not established; limited data suggest off-label dose of 3 mg/m²/dose IV loading dose, then 1.5 mg/m²/dose IV once daily

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Interactions

Interaction Checker

anidulafungin and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Candidemia treatment

            • Diarrhea (3%)
            • Hypokalemia (3%)
            • Abnl LFTs (2%)

            Esophageal Candidiasis treatment

            • Headache (1%)
            • Nausea (1%)
            • Neutropenia (1%)
            • Rash (1%)

            Frequency Not Defined

            Possible histamine-mediated symptoms reported including rash, urticaria, flushing, pruritus, bronchospasm, dyspnea, and hypotension; infrequent when infusion rate does not exceed 1.1 mg/minute.

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            Warnings

            Contraindications

            Hypersensitivity to any component or other echinocandins

            Cautions

            Abnormal LFTs observed; monitor for potential hepatic problems

            May cause bronchospasm

            Not studied for Candida-caused endocarditis, osteomyelitis or meningitis

            Not for bolus administration

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known if distributed in breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Vd: 30-50 L

            Half-Life, distribution: 30 min-1 hr

            Half-Life, terminal elim: 40-50 hr

            Protein Bound: 84%

            Peak Plasma: 8.6 mg/L (on 200 mg/100 mg dosing regimen)

            Clearance: 1 L/hr

            Metabolism: not hepatically, not a CYP3A4 substrate

            Excretion: feces 30%, very low in urine

            Mechanism of Action

            Echinocandin - inhibits synthesis of 1,3-beta-D-glucan, an essential component of fungal cell walls

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            Administration

            IV Preparation

            Aseptically reconstitute each 50 mg vial with 15 mL supplied diluent to obtain a 3.33 mg/mL solution

            May store at 25°C (77°F) - do not freeze

            Administer within 24 hr post-reconstitution

            Dilute further by transferring aseptically in a bag or bottle containing D5W or NS to provide an infusion solution of 0.5 mg/mL

            Discard if particulate matter or discoloration appears

            IV Administration

            Infuse at NMT 1.1 mg/min

            Do not give bolus

            Storage

            Unopened vials, reconstituted vials & diluted solution may be stored at 25°C (77°F) - do not freeze

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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