Dosing & Uses
Dosage Forms & Strengths
- 0.5% (Carac)
- 1% (Fluoroplex)
- 4% (Tolak)
- 5% (Efudex)
- 2% (Efudex)
- 5% (Efudex)
Actinic (Solar) Keratoses
Carac: Apply thin film to affected area qDay for 2-4 wk; healing may not be evident for 1-2 months
Efudex (2% solution): Apply sufficient amount to cover lesions q12hr for 2-4 wk; healing may not be evident for 1-2 months
Fluoroplex: Apply sufficient amount to cover lesions q12hr for 2-6 wk
Tolak (face, ears, or scalp): Apply sufficient amount to cover lesions of affected area(s) qDay for 4 weeks
Superficial Basal Cell Carcinoma
Efudex 5%: Apply sufficient amount of cream or solution to cover lesions q12hr for 3-6 wk; may continue application for up to 10-12 weeks
Frequency Not Defined
Allergic contact dermatits
Hypersensitivity to any component
Women who are or may become pregnant
Dihydropyrimidine Dehydrogenase (DPD) deficiency
Potential for delayed hypersensitivity reaction to fluorouracil
Occlusive dressings may increase inflammatory reaction in adjacent normal skin
Possibility for increased absorption through inflamed or ulcerated skin
Avoid prolonged exposure to sunlight or other UV irradiation
Superficial BCC treatment only when conventional methods are impractical, since conventional methods have better response rate
Pregnancy & Lactation
Pregnancy Category: X
Lactation: Unknown; not recommended
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Interferes with synthesis of DNA & to a lesser extent, RNA
Absorption: Insignificant (~6%)
Time to peak: 1 hr
Apply q12hr with nonmetallic applicator, gloved hands or fingertips
If fingertips used, wash hands immediately afterwards
Solution considered more effective than cream for equivalent strength
Complete healing of lesions typically not evident for 1-2 months
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|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
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