Brand and Other Names:Elmiron
- Classes: Analgesics, Urinary
Dosing & Uses
Dosage Forms & Strengths
Indicated for bladder pain associated with interstitial cystitis
100 mg PO q8hr
Administration: 1 hour before or 2 hours after meals with water
Reassess every 3 Months
Sickle Cell Disease (Orphan)
Orphan indication sponsors
- Vanguard Therapeutics, Inc; Eagle Trace Dr; Half Moon Bay, CA 94019
- TRF Pharma, Inc; 863 Mitten Road; Burlingame, CA 94010
Brand name: Lysosan
Orphan designation for treatment of MPS type VI
- Plexcera Therapeutics, LLC; 4445 North Highway A1A, Suite 241; Vero Beach, FL 32963
<16 years: Safety and efficacy not established
Abdominal pain (2%)
Partial thromboplastin time increased
Prothrombin time increased
Hepatic or splenic disorders
Risk of alopecia
Pregnancy & Lactation
Pregnancy Category: B
Lactation: not known if excreted in breast milk, use caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Low molecular weight heparin-like compound; elicits weak anticoagulant (1/15 activity of heparin) and fibrinolytic effects
MOA in cystitis unknown; drug appears to attach to the bladder wall mucosa where it may act as a buffer to protect tissues from irritating substances in the urine
Half-Life, Elimination: 4.8 hr
Distribution: Uroepithelium of the genitourinary tract with lesser amounts found in the liver, spleen, lung, skin, periosteum, and bone marrow
Metabolism: Spleen and liver; partial depolymerization in the kidney to a large number of metabolites
Excretion: Feces (58% as unchanged drug) Urine (6% primarily as metabolites)
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