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estramustine (Rx)Brand and Other Names:Emcyt

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

capsule

  • 140mg
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Prostate Carcinoma

Palliative treatment of metastatic and/or progressive prostate carcinoma

14 mg/kg divided q6-8hr PO 

Treat for 30-90 days to determine benefits of continued therapy; continue treatment as long as favorable response lasts

Administration

Take 1 hr before or 2 hr after meals

Avoid calcium-rich foods

Not recommended

Prostate Carcinoma

Palliative treatment of metastatic and/or progressive prostate carcinoma

14 mg/kg PO divided q6-8hr  

Treat for 30-90 days to determine benefits of continued therapy; continue treatment as long as favorable response lasts

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Interactions

Interaction Checker

estramustine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Edema

            Dyspnea

            Nausea

            Diarrhea

            Breast tenderness and enlargement

            1-10%

            Lethargy

            Insomnia

            Cerebrovascular accident

            Myocardial infarction

            Thrombophlebitis

            Pulmonary embolism

            Congestive heart failure

            Easy bruising

            Anorexia

            Vomiting

            Pruritus

            Dry skin

            Impotence

            Leg cramps

            Leukopenia

            Decreased testosterone

            Abnormality of hepatic enzymes and/or bilirubin

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            Warnings

            Contraindications

            Hypersensitivity to estradiol or nitrogen mustard

            Active thrombophlebitis or thromboembolic disorder, except when tumor mass is cause of thromboembolic phenomenon & benefits of therapy outweigh risk

            Cautions

            Increased risk of thrombosis, including fatal & non-fatal MI

            Liver dysfunction, metabolic bone disease associated with hypercalcemia, renal insufficiency

            History of thromoboembolic phenomenon especially associated with estrogen therapy

            Decreased glucose tolerance-monitor diabetics

            Risk of HTN-monitor BP periodically

            May cause fluid retention with exacerbation of CHF, peripheral edema, or conditions influenced by fluid retention, such as epilepsy, migraine, renal dysfunction

            May cause gynecomastia & impotence

            Allergic reactions, including angioedema of airway has been reported

            Avoid becoming pregnant

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            Pregnancy & Lactation

            Pregnancy Category: X

            Lactation: not intended for use in women

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Has the effects of estradiol and nitrogen mustard combination. It may inhibit tubulin function by binding to microtubule proteins. Antitumor effects may result from estrogenic effect. Plasma testosterone levels decrease while estrogen levels increase

            Pharmacokinetics

            Absorption: 75% (PO)

            Metabolism: Liver

            Metabolite: estramustine, estradiol, estrone

            Half-life elimination: 15-24hr

            Excretion: Feces (2.9-4.8%)

            Time to peak serum: 2-3 hr

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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