mebendazole (Rx)Brand and Other Names:Emverm

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet, chewable

  • 100mg

Pinworm (Enterobius vermicularis)

100 mg PO as a single dose

If cure is not achieved 3 wk after treatment, a second course of treatment is advised

Roundworm (Ascaris lumbricoides), Whipworm (Trichuris trichiura), Hookworm (Ancylostoma duodenale, Necator americanus)

100 mg PO q12hr for 3 days

If cure is not achieved 3 wk after treatment, a second course of treatment is advised

Giardia Duodenalis (Giardiasis; Off-label)

200 mg PO q8hr for 5 days

Mansonella Perstans (Filariasis; Off-label))

100 mg PO q12hr

Visceral Larva Migrans (Toxocariasis; Off-label)

100-200 mg PO q12hr for 5 days

Dosage Forms & Strengths

tablet, chewable

  • 100mg

Pinworm (Enterobius vermicularis)

100 mg PO as a single dose

If cure is not achieved 3 wk after treatment, a second course of treatment is advised

Roundworm (Ascaris lumbricoides), Whipworm (Trichuris trichiura), Hookworm (Ancylostoma duodenale, Necator americanus)

100 mg PO q12hr for 3 days

If cure is not achieved 3 wk after treatment, a second course of treatment is advised

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Interactions

Interaction Checker

mebendazole and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Angioedema

            Fever

            Dizziness

            Headache

            Hematuria

            Leukopenia

            Seizures

            Drowsiness

            Decreased hemoglobin

            Rash

            Itching

            Agranulocytosis

            Alopecia (with high doses)

            Abdominal pain

            Diarrhea

            Nausea

            Toxic epidermal necrolysis

            May increase AST, ALT, and GGT (hepatitis)

            Stevens-Johnson syndrome

            Vomiting

            Neutropenia (sore throat, unusual fatigue)

            Toxic epidermal necrolysis

            Unusual weakness

            Glomerulonephritis

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Neutropenia and agranulocytosis reported with high doses

            Not effective for hydatid disease

            Systemic exposure may increase with hepatic impairment

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Excretion in breast milk unknown; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Blocks glucose uptake; inhibits the formation of helminth microtubules in susceptible adult intestine-dwelling helminths

            Absorption

            Absorption: 2-10%

            Peak serum time: 2-4 hr

            Distribution

            Distribution: To serum, cyst fluid, liver, omental fat, and pelvic, pulmonary, and hepatic cysts; highest concentrations found in liver; relatively high concentrations found in muscle-encysted Trichinella spiralis larvae; crosses placenta

            Protein bound: 90-95%

            Vd: 1-2 L/kg

            Metabolism

            Metabolism: Extensively hepatic

            Elimination

            Half-life elimination: 3-6 hr

            Excretion: Feces (primarily); urine (~2%)

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            Administration

            Oral Administration

            May be swallowed whole, chewed, or crushed and mixed with food

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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