Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

edrophonium (Rx)Brand and Other Names:Enlon, Enlon Plus, more...Tensilon

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 10mg/mL
more...

Myasthenia Gravis, Diagnosis

2 mg IV push over 15-30 seconds

If muscarinic side effects, fasciculations, & increased muscle weakness occur, discontinue test & give 0.4-0.5 mg atropine IV

If no response, give 8 mg after 45 seconds

May repeat test 30 minutes later

Reversal of Nondepolarizing Neuromuscular Blockers

10 mg IV over 30-45 sec q5-10min PRN

Not to exceed 40 mg

Terminate Paroxysmal Atrial Tachycardia

10 mg IV bolus into IV infusion line (5-7 mg in elderly/digitalized patients)

Dosage Forms & Strengths

injectable solution

  • 10mg/mL
more...

Myasthenia Gravis, Diagnosis

Infants

  • 0.5-1 mg IM
  • 0.1 mg followed by 0.4 mg if no response; not to exceed 0.5 mg

Children

  • Initial: 0.04 mg/kg IV x1 (no more than 5 mg for <34 kg, 2 mg for >34 kg) 
  • If no response after 1 minute: 0.16 mg/kg IV x1
  • Total dose should not exceed 0.5 mg for infants, 5 mg for <34 kg; 10 mg for >34 kg
Next

Interactions

Interaction Checker

edrophonium and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            Less severe & more short-lived than other cholinergic drugs

            Frequency Not Defined

            Nausea/vomiting

            Increased peristalsis

            Increased salivation

            Urinary urgency

            Weakness

            Muscle cramps

            Lacrimation/small pupils

            Hypotension

            Arrhythmia

            Bradycardia

            Laryngospasm

            Cardiac standstill (rare)

            Previous
            Next

            Warnings

            Contraindications

            Hypersensitivity (some experts state may be used in small amounts w/ atropine)

            GI & urinary obstructions

            Cautions

            Use caution in epilepsy, asthma, recent MI, hyperthyroidism, arrhythmias, peptic ulcer, patients receiving cardiac glycosides

            Pregnancy (possible risk of uterine irritability & premature labor)

            May be of limited usefulness in surgery due to brief duration

            Higher doses should be preceded by atropine

            Use in myathenia gravis may exacerbate muscle weakness

            Risk of cholinergic crisis with overdose, which can be fatal

            Does not antagonize, & in fact may prolong, phase I muscle relaxation by depolarizing neuromuscular blockers (eg, succinylcholine)

            Previous
            Next

            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excretion in milk unknown

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Inhibits destruction of acetylcholine by cholinesterase; facilitates transmission of impulses across myoneural function, which results in increased cholinergic responses such as miosis

            Phamacokinetics

            Onset: 30-60 sec (IV); 2-10 min (IM)

            Duration: 10 min (IV); 5-30 min (IM)

            Vd: 1.1 L/kg

            Half-life:1.2-2.4 hr (adults); 2.4-4.4 hr (anephric patients)

            Excretion: Urine

            Previous
            Next

            Administration

            IV Compatibilities

            Y-site: heparin, hydrocortisone Na-succinate, KCl, Vit B/C

            IV Administration

            IV push

            For off-label use in cardiac arrhythmias, has been infused at 0.25-2 mg/min

            Previous
            Next

            Images

            Previous
            Next

            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
            Select State:
            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.