Dosing & Uses
Dosage Forms & Strengths
Apply thin film to affected areas of the face and/or trunk qPM after washing
Dosage Forms & Strengths
<9 years: Safety and efficacy not established
≥9 years: Apply thin film to affected facial areas and/or trunk qPM after washing
Stinging/ burning (3-41%)
Contact dermatitis (3%)
Application site burning (2%)
Application site irritation (1%)
Skin irritation (1%)
Allergic contact dermatitis
Local skin pain
Hypersensitivity to adapalene, benzoyl peroxide or any of its components
Avoid eyes, lips, and mucous membranes
For external use only
Minimize UV light exposure; use sunscreen and protective clothing
Extreme weather (eg, wind, cold) may cause skin irritation
Adverse reaction risk higher during first month of treatment; generally subsides with use
Do not apply to abrasions, cuts, eczematous or sunburned skin
Skin irritation: Apply moisturizer, reduce application frequency, or discontinue
Do not wax treated area or apply topical products that may further irritate skin (eg, astringents, abrasive soaps and cleansers, exfoliants)
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Unknown whether distributed in breast milk, exercise caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Adapalene: Binds to specific retinoic acid nuclear receptors and modulates cellular differentiation, keratinization and inflammatory processes; exact mechanism of action for treatment of acne is unknown
Benzoyl peroxide: Elicits action by releasing active oxygen; effective in vitro against Propionibacterium acnes, an anaerobe found in sebaceous follicles and comedones; also elicits a keratolytic and desquamative effect which may also contribute to its efficacy
Absorption: Benzoyl peroxide absorbed by the skin where it is converted to benzoic acid
Excretion: adapalene (bile), benzoyl peroxide (urine)
For topical use only; not for ophthalmic, oral, or intravaginal use
Avoid mucous membranes, eyes, and lips
Apply pea-sized amount for each facial area (eg, chin, forehead, cheek)
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.