adapalene/benzoyl peroxide (Rx)

Brand and Other Names:Epiduo, Epiduo Forte
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

adapalene/benzoyl peroxide

topical gel

  • 0.1%/2.5%
  • 0.3%/2.5%
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Acne Vulgaris

Apply thin film to affected areas of the face and/or trunk qPM after washing

Dosage Forms & Strengths

adapalene/benzoyl peroxide

topical gel

  • 0.1%/2.5%
  • 0.3%/2.5%
more...

Acne Vulgaris

<9 years: Safety and efficacy not established

≥9 years: Apply thin film to affected facial areas and/or trunk qPM after washing

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Adverse Effects

>10%

Stinging/ burning (3-41%)

Dryness (1-41%)

Scaling (1-35%)

Erythema (1-27%)

1-10%

Contact dermatitis (3%)

Application site burning (2%)

Application site irritation (1%)

Skin irritation (1%)

Postmarketing Reports

Allergic contact dermatitis

Blister

Conjunctivitis

Eczema

Eyelid edema

Local skin pain

Pruritus

Rash

Swelling

Skin discoloration

Sunburn

Throat tightness

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Warnings

Contraindications

Hypersensitivity to adapalene, benzoyl peroxide or any of its components

Cautions

Avoid eyes, lips, and mucous membranes

For external use only

Minimize UV light exposure; use sunscreen and protective clothing

Extreme weather (eg, wind, cold) may cause skin irritation

Adverse reaction risk higher during first month of treatment; generally subsides with use

Do not apply to abrasions, cuts, eczematous or sunburned skin

Skin irritation: Apply moisturizer, reduce application frequency, or discontinue

Do not wax treated area or apply topical products that may further irritate skin (eg, astringents, abrasive soaps and cleansers, exfoliants)

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Unknown whether distributed in breast milk, exercise caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
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Pharmacology

Mechanism of Action

Adapalene: Binds to specific retinoic acid nuclear receptors and modulates cellular differentiation, keratinization and inflammatory processes; exact mechanism of action for treatment of acne is unknown

Benzoyl peroxide: Elicits action by releasing active oxygen; effective in vitro against Propionibacterium acnes, an anaerobe found in sebaceous follicles and comedones; also elicits a keratolytic and desquamative effect which may also contribute to its efficacy

Pharmacokinetics

Absorption: Benzoyl peroxide absorbed by the skin where it is converted to benzoic acid

Excretion: adapalene (bile), benzoyl peroxide (urine)

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Administration

Instructions

For topical use only; not for ophthalmic, oral, or intravaginal use

Avoid mucous membranes, eyes, and lips

Apply pea-sized amount for each facial area (eg, chin, forehead, cheek)

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Images

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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