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ergoloid mesylates (Rx)Brand and Other Names:Hydergine

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 1mg
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Age-Related Mental Decline & Alzheimer's Dementia

1 mg PO q8hr

May administer up to 4.5-12 mg/day therapeutic trial should be 6 months in duration

Safety & efficacy not established

Age-Related Mental Decline & Alzheimer's Dementia

1 mg PO q8hr

May administer up to 4.5-12 mg/day therapeutic trial should be 6 months in duration

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Interactions

Interaction Checker

ergoloid mesylates and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Flushing

            Headache

            Rash

            Nausea

            Vomiting

            Nasal congestion

            Blurred vision

            Bradycardia or bradyarrhythmia

            Orthostatic hypotension

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            Warnings

            Contraindications

            Hypersensitivity, psychosis; consider other CNS disease before starting

            CYP3A4 inhibitors (azole anifungals, protease inhibitors, macrolide antibiotics)

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            Pregnancy & Lactation

            Pregnancy Category: N/A

            Lactation: unknown

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Contains derivatives of three naturally occurring ergot alkaloids which have some peripheral alpha blocking activity and also depress CNS vasomotor nerve activity resulting in slight decrease in BP and HR; mechanism of action in dementia is largely unknown

            Pharmacokinetics

            Half-Life elimination: 3.5 hr

            Onset: 3-4 wk

            Peak Plasma Time: ~1 hr

            Concentration: 576 pg/mL

            Bioavailability: 9%

            Metabolism: Liver

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            Images

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            Formulary

            FormularyPatient Discounts

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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