Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

ergonovine (Discontinued)Brand and Other Names:ergometrine, Ergotrate

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 0.2mg

injection solution

  • 0.2 mg/mL (1) mL
more...

Pospartum or Postabortion Hemorrhage

0.2 mg IM; may repeat in 2-4hr; not to exceed 5 doses total

Give IV only in emergency because of potential for HTN & CVA

Alternatively, 0.2-0.4 mg PO q6-12hr PRN for 48 hr or until danger of uterine atony has passed; no more than 1 week

Give over >1 minute & monitor BP

Other Indications & Uses

Prevention and treatment of postpartum and postabortion hemorrhage caused by uterine atony or subinvolution

Safety and efficacy not established

Next

Interactions

Interaction Checker

ergonovine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            Frequency Not Defined

            Dizziness

            Headache

            Hypertension

            Nasal congestion

            Nausea and vomiting

            Allergic phenomenon including shock

            Angina

            Arrythmia

            Diaphoresis

            Diarrhea

            Dyspnea

            Foul taste

            Hallucinations

            Hematuria

            Hypertensive episode

            Leg cramps

            Thrombophlebitis

            Tinnitus

            Water intoxication

            Previous
            Next

            Warnings

            Contraindications

            Hypertension, toxemia, pregnancy, hypersensitivity, prolonged use

            Cases of threatened spontaneous abortion

            Avoid during breast-feeding

            Cautions

            If administered during the second or third stage of labor prior to delivery of the placenta, complications such as captivation of the placenta may occur

            In patients with sepsis, hepatic impairment, renal impairment

            Previous
            Next

            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excreted in milk; adverse effect on the nursing infant; may inhibit lactation; use not recommended

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Produces vasoconstriction to increased strength, duration, and frequency of uterine contraction which in turn impedes uterine blood flow; shortens the third stage of labor

            Pharmacokinetics

            Half-Life: 1-5 min (initial phase); 0.5-2 hr (terminal phase)

            Plasma peak time: 30 min

            Concentration: 3 ng/mL

            Duration in uterine effects: 3 hr (IM); 45 min (IV)

            Onset: Uterine contractions are usually initiated within 5-15 min following oral administration, within 2-3 min after IM injection, and 1 min following IV injection

            Metabolism: Liver

            Excretion: Feces

            Previous
            Next

            Administration

            IV Administration

            Give IV only in emergency because of potential for HTN & CVA

            Give over >1 min & monitor BP

            Previous
            Next

            Images

            Previous
            Next
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.