Ginkgo Biloba (Herbs/Suppl)

Brand and Other Names:Eun-haeng, fossil tree, more...ginko biloba, ginkyo, icho, ityo, Japanese silver apricot, kew tree, maidenhair tree, salisburia, silver apricot
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Suggested Dosing

Altitude Sickness, Prevention

Leaf extract: 80 mg PO BID

Cognitive Function

Leaf extract: 120-600 mg/d PO BID

Dementia

Leaf extract: 120-240 mg/d PO div BID-TID

Intermittent Claudication

Leaf extract: 120-240 mg/d PO div BID-TID

Premenstrual Syndrome

Leaf extract: 80 mg PO BID; start on day 16 and continue until day 5 of next cycle

SSRI-induced Sexual Dysfunction

Leaf extract: 60-240 mg PO BID

Vertigo/tinnitus

Leaf extract: 120-160 mg/d PO div BID-TID

Raynaud's Disease

Leaf extract: 360 mg/d PO div TID

Normal Tension Glaucoma

Leaf extract: 40 mg PO TID x 4 weeks

Other Information

Standardized to 24% flavonoids, 6% terpenes

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Suggested Uses

Altitude sickness (prevention), cerebral vascular insufficiency, cognitive disorders, dementia, dizziness/vertigo, intermittent claudication, macular degeneration/glaucoma, memory loss, premenstrual syndrome, SSRI-induced sexual dysfunction, vasodilator

Efficacy

Documented incr in cerbral blood flow (greater effect in patients >50 years old)

Documented increase in peripheral blood flow in diabetes, intermittent claudication, hearing loss

Studies underway for SSRI-induced erectile dysfunction; initial results positive

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Interactions

Interaction Checker

and Ginkgo Biloba

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    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

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            Adverse Effects

            Frequency Not Defined

            Allergic skin reactions

            Bleeding disorders

            Constipation

            Contact dermatitis (topical use)

            Diarrhea

            Dizziness

            Impaired fertility

            GI upset

            Headache

            Nausea/vomiting

            Palpitations

            Restlessness

            Seizures

            Subdural hematoma

            Weakness

            Vertigo (rare)

            Case reports of sponataneous bleeding from iris when used with aspirin

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            Warnings

            Contraindications

            Hypersensitivity

            Avoid prior to surgery: may cause bleeding

            Attempting conception

            Cautions

            Bleeding disorders, concurrent seizure threshold lowering drugs, diabetes mellitus, seizure disorder

            WARNING: seeds & fruit pulp are toxic

            May modulate some CYP 450 enzymes but clinical significance unknown, monitor when using concomitant substrates (eg, CYP3A4)

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            Pregnancy & Lactation

            Pregnancy Category: N/A

            Lactation: N/A

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Ginkgoflavone glycosides: reduce capillary fragility, act as antioxidants

            Ginkgolides: inhib. platelet activating factor

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