ferrous gluconate (OTC)

Brand and Other Names:Fergon
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 225mg (27mg elemental iron)
  • 240mg (27mg elemental iron)
  • 246mg (28mg elemental iron)
  • 324mg (38mg elemental iron)
  • 325mg (36mg elemental iron)
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Iron Deficiency Anemia

Treatment: 60 mg elemental Fe PO q6-12hr

Prophylaxis: 60 mg elemental Fe PO qDay

Recommended Daily Intake

Men: 8 mg elemental Fe PO qDay

Women: 18 mg elemental Fe PO qDay

Pregnant women: 27 mg elemental Fe PO qDay

Lactating women: 9 mg elemental Fe PO qDay

Dosage Forms & Strengths

tablet

  • 225mg (27mg elemental iron)
  • 240mg (27mg elemental iron)
  • 246mg (28mg elemental iron)
  • 324mg (38mg elemental iron)
  • 325mg (36mg elemental iron)
more...

Iron Deficiency Anemia

Treatment: 3-6 mg elemental Fe/kg/day PO  

Prophylaxis: 1-2 mg elemental Fe/kg/day PO; not to exceed 15 mg/day

Recommended Daily Intake

0-6 months: 0.27 mg elemental Fe PO qDay

7-12 months: 11 mg elemental Fe PO qDay

1-3 yr: 7 mg elemental Fe PO qDay

4-8 yr: 10 mg elemental Fe PO qDay

9-13 yr: 8 mg elemental Fe PO qDay

14-18 Years

  • Males: 11 mg elemental Fe PO qDay
  • Females: 15 mg elemental Fe PO qDay
  • Pregnant females: 27 mg elemental Fe PO qDay
  • Lactating females: 10 mg elemental Fe PO qDay

Lower doses of 10-50 mg elemental iron/day recommended may cause fewer GI adverse ements

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Interactions

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            Adverse Effects

            Frequency Not Defined

            GI irritation

            Nausea

            Stomach cramping

            Staining of teeth

            Heartburn

            Vomiting

            Constipation

            Diarrhea

            Discoloration of urine

            Dark color stools

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            Warnings

            Black Box Warnings

            Severe iron toxicity may occur in overdose, particularly when ingested by children; iron is a leading cause of fatal poisoning in children younger than 6 yr; store out of children’s reach and in children-resistant containers

            Contraindications

            Hypersensitivity

            Hemochromatosis

            Hemosiderosis

            Hemolytic anemia

            Anemia other than iron-deficiency anemia

            Cautions

            Oral absorption variable and incomplete

            Avoid with peptic ulcer, enteritis, or ulcerative colitis

            Avoid with frequent blood transfusions

            Iron stores in elderly are usually normal; anemia of chronic disease often seen in elderly is caused by inability of reticuloendothelial system to use available iron stores

            Premature infants with vitamin E deficiency: administration of Fe may cause red cell hemolysis and hemolytic anemia

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            Pregnancy & Lactation

            Pregnancy Category: A; pregnant women typically require increased iron ingestion to meet dietary requirements (see dosing sections)

            Lactation: Distributed in breast milk, considered safe for breast feeding; breast milk generally provides enough iron to meet infant nutritional requirement; amount of iron in breast milk typically not influenced by maternal iron status

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Essential nutrient, component of heme and nonheme iron proteins; ferrous gluconate contains 12% elemental Fe

            Pharmacokinetics

            Absorption: 10-35% (normal Fe stores); 80-95% (depleted iron stores); food decreases absorption by up to 60%

            Onset: 1 week

            Excretion: Urine (trace), feces (trace), sweat, sloughing intestinal mucosal cells, menses (women)

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            Administration

            Oral Administration

            For maximum absorption take on empty stomach, but may take with or after meals to minimize GI irritation

            Vitamin C may enhance absorption

            May administer in divided daily doses q8-12hr

            Antacids may interfere with absorption; administer 2 hr before or 4 hr after antacids

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