1 tbsp PO BID-TID
15-30 ml PO qDay
equivalent to 200 mg ALA qDay
30-50 g topically PRN
Take with adequate amount of fluid to prevent bowel obstruction
Constipation (chronic), benign prostatic hyperplasia (oil), cancer (prevention), diabetes, diverticulitis, gastritis/enteritis, hypercholesterolemia, irritable bowel syndrome, menopausal symptoms, MI prevention (oil), skin inflammation, SLE nephritis
Possibly effective for diabetes, hypercholesterolemia, menopausal symptoms and SLE nephritis.
Serious - Use Alternative
Significant - Monitor Closely
Allergic reactions, anaphylactoid rxns, diarrhea (oil), intestinal obstruction
Bowel obstruction, cancer (breast, ovarian, uterine), endometriosis, esophageal stricture, hormone sensitive conditions, hypertriglyceridemia, intestinal inflammation, acute, uterine fibroids
Bleeding disorders (oil)
Pregnancy & Lactation
Pregnancy Category: avoid use
Lactation: avoid use
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Seeds: bulk-forming laxative; prevent enterohepatic recirculation of cholesterol
Oil: source of alpha-linolenic acid, an essential component of cell membranes & precursor for anti-inflammatory prostaglandins