flupenthixol (Discontinued) - Fluanxol

 
 
 

Adult Dosing & Uses

Not available in United States

Fluanxol Depot (Flupenthixol Decanoate)

20-40 mg IM preferably in gluteus maximus

Follow with 2nd dose of 20-40 mg 4-10 days after 1st injection, THEN

20-40 mg IM q2-3week

Test first in patients not exposed to long-acting depot antipsychotics, geriatric, frail/cachectic, pts with EPS predisposition with 5 mg IM

May use 10% IM solution on patients requiring higher doses or uncomfortable with large-volume injections

Fluanxol Tabs (Flupenthixol Dihydrochloride)

1 mg TID

May be increased by 1 mg q2-3d

Usual maint dose 3-6 mg/d in divided doses

Up to 12 mg/d has been used

May be switched to IM after stabilization

Other Indications & Uses

Maintenance of chronic schizophrenia without agitation, excitement or hyperactivity

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Pediatric Dosing & Uses

Not recommended

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Drug Interactions

Interaction Checker

flupenthixol and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            EPS (30%)

            Frequency Not Defined

            Tardive dyskinesia

            Pseudoparkinsonism

            Dystonia

            Akathisia

            Dry mouth

            Blurred vision

            Excessive perspiration

            Excessive salivation

            Micturition difficulties

            Palpitations

            Weight change

            Elevated prolactin

            Galactorrhea

            Loss of libido

            Impotence

            Eosinophilia

            Jaundice

            Incr liver enzymes (AST, ALT, alk phos)

            Nausea

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            Contraindications & Cautions

            Contraindications

            Hypersensitivity to thioxanthenes

            Severely agitated psychotics, psychoneuroses

            CNS depression due to any cause, brain damage, comatose state

            Circulatory collapse, blood dyscrasias, pheochromocytoma

            Geriatric pts with confusion or agitation

            Cardiac or renal insufficiency

            Not for IV

            Cautions

            Pregnancy, lactation, breast cancer, glaucoma, history of convulsive d/o

            Potential for tardive dyskinesia on long-term tx

            Depot inj: ensure by aspiration after insertion of needle that inadvertent IV inj doesn't occur

            Do not use epinephrine if hypotension occurs

            Do not use with large doses of hypnotics

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            View Category Definitions

            Pregnancy & Lactation

            Pregnancy Category: not available

            Lactation: enters breast milk; not recommended

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Peak Plasma Time

            IM: 4-7 d

            PO: 3-8 hr

            Other Information

            Metabolism: unknown, apparently inactive metabolites

            Excretion: mainly feces, small portion in urine

            Mechanism of Action

            Thioxanthene, unknown mechanism

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