rimantadine (Rx)

Brand and Other Names:Flumadine
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

syrup

  • 50mg/5mL

tablet

  • 100mg
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Influenza A Virus

Prophylaxis

  • 100 mg PO q12hr

Treatment

  • 100 mg PO q12hr preferably within 48 hours after onset of signs and symptoms of influenza A infection

Dosage Forms & Strengths

tablet

  • 100mg
more...

Influenza A Virus

Children 1-10 years and Children >10 years but <40 kg: 5 mg/kg PO qDay or q12hr; not to exceed 150mg/day 

Children >10 years and >40 kg: 100mg PO q12hr

Severe renal (CrCl <10 mL/min) or liver impairment: Administer qDay

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Interactions

Interaction Checker

and rimantadine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Dizziness (2%)

            Nervousness (1-2%)

            Fatigue (1%)

            Headache (1%)

            Insomnia (2%)

            Difficulty in concentrating (<2%)

            Anxiety (1%)

            Anorexia (2%)

            Weakness (1%)

            Nausea (3%)

            Vomiting (2%)

            Xerostomia (2%)

            Abdominal pain (1%)

            Anorexia (2%)

            < 1%

            Dyspnea

            Agitation

            Ataxia

            Tachycardia

            Tremor

            Convulsions

            Heart block

            Hyperkinesias

            Bronchospasm

            Gait abnormality

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            Warnings

            Contraindications

            Hypersensitivity to amantadine, rimantadine or any drug component

            Cautions

            CDC advises against use for treatment or prophylaxis of influenza in the US during the 2008-09 influenza season

            Caution in patients with history of seizures; discontinue if seizures occur

            Avoid use in patients with psychosis (active or uncontrolled)

            Caution in renal impairment

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: enters breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Inhibits viral replication of three subtypes of influenza A (H1N1, H2N2, H3N2) early in the viral replicative cycle. Has no activity against influenza B virus.

            Pharmacokinetics

            Onset of action: antiviral activity: no data exist establishing a correlation between plasma concentration & antiviral effect

            Absorption: tablet and syrup formulations are equally absorbed

            Metabolism: Hepatic (extensive)

            Protein binding: 40% (primarily to albumin)

            Half-life: 25.4 hr; prolonged in elderly as well as severe renal and hepatic impairment

            Peak Plasma Time: 6 hr

            Excretion: Urine (<25% as unchanged drug)

            Clearance: Hemodialysis does not contribute to clearance

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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