influenza virus vaccine intranasal (Rx) - FluMist, FluMist Quadrivalent

 
 
 

Adult Dosing & Uses

Dosing Forms & Strengths

FluMist

(intranasal)

  • 0.2mL (prefilled single use sprayer)

Contains the following 3 viral strains for 2011/2012 season

  • A/California/7/2009 (H1N1)-like (same strain as was used for 2009 H1N1 monovalent vaccines)
  • A/Perth/16/2009 (H3N2)-like
  • B/Brisbane/60/2008-like

FluMist Quadrivalent

(intranasal)

  • 0.2mL (prefilled single use sprayer)

Contains the following 4 viral strains for 2012/2013 season

  • A/California/7/2009 (H1N1)-like (same strain as was used for 2009 H1N1 monovalent vaccines)
  • A/Perth/16/2009 (H3N2)-like
  • B/Yamagata/16/88
  • B/Victoria/2/87

Prevention of influenza A & B infection

CDC's ACIP recommends that everyone 6 months of age and older receive an annual influenza vaccination

Age <50 years: 0.2 mL/dose (0.1 mL/nostril); 1 dose/season

Intranasal administration for age 50 years or older: Safety and efficacy not established

Additional Information

Current vaccination schedules available at www.cdc.gov/nip/publications

Other Indications & Uses

Prevention of influenza A and B infection for patients aged 2-49 years

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Pediatric Dosing & Uses

Dosing Forms & Strengths

FluMist

(intranasal)

  • 0.2mL (prefilled single use sprayer)

Contains the following 3 viral strains for 2011/2012 season

  • A/California/7/2009 (H1N1)-like (same strain as was used for 2009 H1N1 monovalent vaccines)
  • A/Perth/16/2009 (H3N2)-like
  • B/Brisbane/60/2008-like

FluMist Quadrivalent

(intranasal)

  • 0.2mL (prefilled single use sprayer)

Contains the following 4 viral strains for 2012-2013 season

  • A/California/7/2009 (H1N1)-like (same strain as was used for 2009 H1N1 monovalent vaccines)
  • A/Perth/16/2009 (H3N2)-like
  • B/Yamagata/16/88
  • B/Victoria/2/87

Prevention of influenza A & B infection

CDC's ACIP recommends that everyone 6 months of age and older receive an annual influenza vaccination

Intranasal administration <2 year: Safety and efficacy not established

2-8 years and not vaccinated prevoiusly with influenza vaccine: 0.2 mL/dose (0.1 mL in each nostril); give 2 doses each at least 1 month apart

2-8 years previously vaccinated with influenza vaccine: As in adults; 0.2 mL/dose (0.1 mL/nostril); 1 dose/season

>9 years: As in adults; 0.2 mL/dose (0.1 mL/nostril); 1 dose/season

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Drug Interactions

Interaction Checker

influenza virus vaccine intranasal and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Adults

            • Runny nose (41-45%)
            • Headache (41-45%)
            • Sore throat (26-30%)
            • Weakness (26-30%)
            • Myalgia (16-20%)
            • Cough (11-15%)

            Children

            • Runny nose/nasal congestion (46-50%)
            • Cough (36-40%)
            • Irritability (16-20%)
            • Headache (16-20%)

            1-10%

            Adults

            • Chills (6-10%)
            • Nasal congestion (6-10%)
            • Sinusitis (2-5%)
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            Contraindications & Cautions

            Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967

            Contraindications

            Hypersensitivity to eggs, sulfites

            Do not admin. IV/IM

            Children/adolescents receiving aspirin

            History of Guillain-Barre

            Patients <2 yr, > 49 yr

            Asthma, reactive airway disease

            Diabetes, renal dysfunction

            Hemoglobinopathies

            Immunodeficiency diseases

            On immunosuppressants

            Any chronic pulmonary/cardivascular disorder

            Cautions

            Administer 48 hr after cessation of antiviral reactions

            Do not administer within 2 wk of inactivated vaccine or 4 week of live virus vaccine

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            View Category Definitions

            Pregnancy & Lactation

            Pregnancy Category: C

            Live virus vaccine; indicated for nonpregnant adolescents and adults

            Lactation: unknown; avoid intranasal live vaccine while breastfeeding newborn

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Vaccine; vaccines convey active immunity via stimulation of production of endogenously produced antibodies

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