influenza virus vaccine (Rx) - Fluzone, Afluria, more..Fluarix, FluLaval, Fluvirin, Fluzone High-Dose, Fluzone Intradermal

 
 
 

Adult Dosing & Uses

Dosing Forms & Strengths

IM injection, regular strength

  • 22.5mcg/0.25mL
  • 45mcg/0.5mL

IM injection, high-dose

  • 180mcg/0.5mL

ID injection

  • 27mcg/0.1mL

Contains the following 3 influenza strains for 2011/2012 season

  • A/California/7/2009 (H1N1)-like (same strain as was used for 2009 H1N1 monovalent vaccines)
  • A/Perth/16/2009 (H3N2)-like
  • B/Brisbane/60/2008-like

Influenza Prophylaxis

CDC's ACIP recommends that everyone 6 months of age and older receive an annual influenza vaccination

IM regular strength

  • 0.5 mL IM x1 dose

Fluzone Intradermal

  • 18-64 years: 0.1 mL ID x1 dose

Geriatrics

Fluzone High-Dose: 0.5 mL IM x1 dose for adults 65 yr or older

Administration

Administer at beginning of influenza season

Other Information

Healthcare workers are large reservoir for influenza, estimated only 60% currently immunized

Healthy children age 6-23 months are most likely to be hospitalized from influenza

Immunization of household contacts of young children prevent spreading influenza to infants/toddlers

Pregnant and breastfeeding women: Risk of serious cardiorespiratory complications of influenza include increased heart rate, stroke volume, and O2 consumption, and decreased lung capacity; vaccine safe in all 3 trimesters

Patients aged 49-64 years often have increased prevalence of high-risk conditions

65 years or older, or residents of nursing homes should be vaccinated and are at higher risk for mortality from influenza

Up-to-date vaccination schedules available at www.cdc.gov/nip/publications

Other Indications & Uses

For children and teens age 6 months through 18 years, as well as all household contacts of infants and children through age 59 months (ie, 4 years 11 months)

Patients >19 yo with risk factor (eg, pregnancy, heart or lung disease, renal, hepatic, hematologic, or metabolic disorder [including diabetes], immunosuppression, or have a condition that compromises respiratory function or the handling of respiratory secretions or that can increase the risk of aspiration) or live in a chronic-care facility;

Persons who live or work with at-risk people as listed above

Persons who want to reduce the likelihood of becoming ill with influenza or of spreading it to others

Next

Pediatric Dosing & Uses

Dosing Forms & Strengths

injection, regular strength

  • 22.5mcg/0.25mL
  • 45mcg/0.5mL

Contains the following 3 influenza strains for 2011/2012 season

  • A/California/7/2009 (H1N1)-like (same strain as was used for 2009 H1N1 monovalent vaccines)
  • A/Perth/16/2009 (H3N2)-like
  • B/Brisbane/60/2008-like

Influenza Prophylaxis

CDC's ACIP recommends that everyone 6 months of age and older receive an annual influenza vaccination

Fluzone

  • Approved for children >6 months
  • 6-18 months: 0.25 mL IM (anterolateral thigh) x1-2 doses/season
  • 18-35 months: 0.25 mL IM (deltoid) x1-2 doses/season
  • 3-9 years old: 0.5 mL IM (deltoid) x1-2 doses/season
  • >9 years old: As in adults
  • Children up to age 9 years old: If receiving influenza vaccine for first time, or vaccinated for the first time last year but only received 1 dose, give 2 doses at least 4 weeks apart
  • Children previously vaccinated with 2 doses should receive only 1 dose

Fluvirin (Inactivated vaccine)

  • <4 years old: Not approved
  • 4-9 years old: 0.5 mL IM (deltoid) x1-2 doses/season
  • >9 years old: As in adults
  • Children up to age 9 years old: If receiving influenza vaccine for first time, or vaccinated for the first time last year but only received 1 dose, give 2 doses at least 4 weeks apart
  • Children previously vaccinated with 2 doses should receive only 1 dose

Fluarix

  • <3 years old: Not approved
  • 3-9 years old: 0.5 mL IM (deltoid) x1-2 doses/season
  • >9 years old: As in adults
  • Children up to age 9 years old: If receiving influenza vaccine for first time, or vaccinated for the first time last year but only received 1 dose, give 2 doses at least 4 weeks apart
  • Children previously vaccinated with 2 doses should receive only 1 dose

Afluria

  • <5 years: Not approved
  • 5-8 years: 0.5 mL IM (deltoid) x1-2 doses/season
  • 9 years or older: As in adults
  • Children up to age 9 years old: If receiving influenza vaccine for first time, or vaccinated for the first time last year but only received 1 dose, give 2 doses at least 4 weeks apart
  • Children previously vaccinated with 2 doses should receive only 1 dose

Administration

Administer at beginning of influenza season

Previous
Next

Drug Interactions

Interaction Checker

influenza virus vaccine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967

            >10%

            Soreness at injection site (10-70%)

            Frequency Not Defined

            Fever

            Malaise

            Myalgia

            Headache

            Allergic reactions

            Previous
            Next

            Contraindications & Cautions

            Contraindications

            Hypersensitivity to eggs, sulfites

            Cautions

            Use split or purified surface antigen in children

            Defer vaccine with febrile illnesses until illness is resolved; may administer vaccine with minor illnesses without fever (eg, URIs)

            Expected immune response may not be obtained in immunocompromised individuals, including those receiving immunosuppressive therapy

            Previous
            Next
            View Category Definitions

            Pregnancy & Lactation

            Pregnancy Category: B/C (manufacturer specific)

            CDC recommends Influenza vaccine be administered during pregnancy (all trimesters); vaccination during pregnancy shown to decrease risk of illness in the mother, as well as the risk of influenza and influenza hospitalization in their infants during the first 6 months of life (MMWR August 26, 2011;60[33]:1128-32)

            Lactation: excretion in milk unknown; use with caution

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            Previous
            Next

            Pharmacology

            Mechanism of Action

            Inactivated influenza virus types A & B subunits

            Convey active immunity via stimulation of production of endogenously produced antibodies

            Pharmacokinetics

            Onset: days

            Duration: few months

            Effectiveness: 70-90%

            Previous
            Next

            Pricing & Images

            Previous
            Next
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
            This website also contains material copyrighted by 3rd parties.

            DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.