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folic acid (Rx, OTC)Brand and Other Names:Folvite

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 400mcg
  • 800mcg
  • 1mg

injectable solution

  • 5mg/mL
more...

Nutritional Supplementation

Recommended daily allowance (RDA)

Males: 400 mcg/day PO

Females: 400-800 mcg/day PO

Pregnant women: 600 mcg/day PO

Nursing women: 500 mcg/day PO

Upper limit: 1 mg/day PO

Neural Tube Defects Prophylaxis

Females of childbearing potential: 400 mcg/day PO

Pregnancy women: 600 mcg/day PO

Females with high risk or family history of neural tube defects: 4 mg/day PO

Folic Acid Deficiency

0.4-1 mg PO/IV/IM/SC once daily

Methanol Toxicity

50-75 mg IV q4hr for 24 hr

Methotrexate Toxicity Prophylaxis (Off-label)

1 mg PO qDay; may increase up to 5 mg/day if toxicity emerges

Dosage Forms & Strengths

tablet

  • 400mcg
  • 800mcg
  • 1mg

injectable solution

  • 5mg/mL
more...

Nutritional Supplementation

RDA

0-6 months: 65 mcg/day PO

7-12 months: 80 mcg/day PO

1-4 years: 150 mcg/day PO

4-9 years: 200 mcg/day PO

9-14 years: 300 mcg/day PO

14-18 years: 400 mcg/day PO

Upper limit: 1-4 years, 300 mcg/day PO; 4-8 years, 400 mcg/day PO

Folic Acid Deficiency

Infants: 15 mcg/kg/day or 50 mcg/day IV/PO/IM/SC  

1-10 years: 1 mg/day IV/PO/IM/SC initially, then 0.1-0.4 mg/day

Methanol Toxicity

1 mg/kg IV q4hr for 24 hr 

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Interactions

Interaction Checker

folic acid and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Bronchospasm

            Erythema

            Malaise

            Pruritus

            Rash

            Slight flushing

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Undiagnosed anemias

            May mask anemia at dosages >0.1 mg/day

            In presence of vitamin B12 deficiency, not appropriate for monotherapy in pernicious, normocytic, or aplastic anemia

            Vials must be protected from heat and light

            Injection contains benzyl alcohol as preservative (benzyl alcohol is associated with gasping syndrome in neonates)

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            Pregnancy & Lactation

            Pregnancy category: A

            Lactation: Drug enters breast milk; safe for nursing

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Necessary for formation of coenzymes in metabolic systems (purine and pyrimidine synthesis required for maintenance in erythropoiesis); stimulates platelet production in folate deficiency anemia

            Enhances elimination of formic acid in methanol toxicity via provision of coenzyme to folate dehydrogenase

            Absorption

            Absorbed in proximal part of small intestine

            Onset: PO, 0.5-1 hr

            Metabolism

            Metabolized in liver

            Elimination

            Excretion: Urine

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            Administration

            IV/IM/SC Administration

            Administer by IV/IM/SC injection only when PO administration is not feasible or when malabsorption is suspected

            Most individuals with malabsorption can absorb oral folic acid

            For IM use, administer by deep injection

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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