Freeze-dried aqueous extract: 100 mg PO qDay
Extract free of tetracyclic oxindole alkaloids: 60 mg PO TID
Arthritis, birth control, bone pains, cancer (urinary tract), intestinal disorders, kidney cleansing, peptic ulcers, viral infections, wound healing, allergic rhinitis, diverticulitis, Alzheimer's disease, and leaky bowel syndrome, herpes simplex, human immunodeficiency virus, CFS
Osteoarthritis: Freeze-dried Uncaria guianensis PO decreases pain related to physical activity. Does not decrease pain at rest or swelling
Rheumatoid arthritis: Uncaria tomoentosa extract PO modestly improves symptoms
Insufficient reliable results for other listed uses
Serious - Use Alternative
Significant - Monitor Closely
Dizziness, headache, hypotension, vomiting
Autoimmune disorders, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus
Concurrent antihypertensives, concurrent CYP3A4 substrates, concurrent immunosupressant therapy, hypotension
Pregnancy & Lactation
Pregnancy Category: avoid use
Lactation: avoid use
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Decreases inflammation via inhibition of NF-kappa b & TNFalpha
Enhances immune function via increase in WBCs
Mytraphylline: diuretic effect
Quinovic acid glycosides: antiviral activity (in vitro)