human papillomavirus vaccine, quadrivalent (Rx) - Gardasil, hpv vaccine, quadrivalent

 
 
 

Adult Dosing & Uses

Dosing Forms & Strengths

vaccine

  • 0.5mL (single-dose vial)

Prevention of Diseases Caused by HPV Types 6, 11, 16, & 18

9-26 years: 0.5 mL IM x3 doses administered at 0, 2, & 6 months

If age 26 yr reached before vaccination series completed, remaining doses can be administered after age 26 yr (CDC guidelines)

Indicated for prevention in girls & women (9-26 years)

  • Cervical, vulvar, and vaginal cancer caused by HPV types 16 & 18
  • Genital warts (condyloma acuminata) caused by HPV types 6 & 11

Precancerous or dysplastic lesions in girls & women (9-26 years) caused by HPV types 6, 11, 16, & 18

  • Cervical intraepithelial neoplasia grade 2/3
  • Cervical adenocarcinoma in situ
  • Cervical intraepithelial neoplasia (CIN) grade 1
  • Vulvar intraepithelial neoplasia (VIN) grade 2/3
  • Vaginal intraepithelial neoplasia (VaIN) grade 2/3

Indicated for prevention in boys & men (9-26 years)

  • Genital warts (condyloma acuminata) caused by HPV types 6 & 11
  • CDC ACIP guidelines recommends routine immunization for all boys aged 11-12 years (MMWR Dec 23, 2011/Vol 60[50];1705-8)
  • Recommended for previously unvaccinated males aged 22–26 years who are immunocompromised, test positive for HIV infection, or who have sex with men

Anal cancer

  • Indicated for prevention of anal cancer and associated precancerous lesions caused by HPV types 6, 11, 16, and 18 people aged 9-26 years

Other Information

Administration: deltoid region of upper arm or higher anterolateral area of thigh

Up-to-date vaccination schedules available at www.cdc.gov/nip/publications

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Pediatric Dosing & Uses

Dosing Forms & Strengths

vaccine

  • 0.5mL (single-dose vial)

Prevention of Diseases Caused by HPV Types 6, 11, 16, & 18

>9 years: as adult; 0.5 mL IM x 3 doses at 1, 2, & 6 months

Indicated for prevention in girls & women (9-26 years)

  • Cervical, vulvar, and vaginal cancer cuased by HPV types 16 & 18
  • Genital warts (condyloma acuminata) caused by HPV types 6 & 11

Precancerous or dysplastic lesions in girls & women (9-26 years) caused by HPV types 6, 11, 16, & 18

  • Cervical intraepithelial neoplasia grade 2/3
  • Cervical adenocarcinoma in situ
  • Cervical intraepithelial neoplasia (CIN) grade 1
  • Vulvar intraepithelial neoplasia (VIN) grade 2/3
  • Vaginal intraepithelial neoplasia (VaIN) grade 2/3

Indicated for prevention in boys & men (9-26 years)

  • Genital warts (condyloma acuminata) caused by HPV types 6 & 11

Anal cancer

  • Indicated for prevention of anal cancer and associated precancerous lesions caused by HPV types 6, 11, 16, and 18 people aged 9-26 years
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Drug Interactions

Interaction Checker

human papillomavirus vaccine, quadrivalent and

No Results

     
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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967

            >10%

            Inj site pain

            Inj site erythema & swelling

            Fever

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            Contraindications & Cautions

            Contraindications

            Hypersensitivity

            <9 yo; >26 yo

            Bleeding d/o, anticoagulant tx (unless benefits outweigh risks)

            Cautions

            Individuals who develop Sx indicative of hypersensitivity after 1st dose should not receive additional doses

            Monitor for 15 min following vaccination for syncope/convulsive syncope

            Not shown to be protective against non-vaccine HPV types

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            View Category Definitions

            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: not known whether excreted in breast milk, use caution

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Duration: unknown

            These products convey active immunity via stimulation of production of endogenously produced antibodies

            The onset of protection from disease is relatively slow, but duration is long lasting (years)

            Mechanism of Action

            Recombinant vaccine prepared from L1 protein of HPV types 6, 11, 16 & 18

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            Pricing & Images

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