ferumoxsil (Rx)

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Brand and Other Names:GastroMark, Primovist

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral solution

  • 175mcg/mL Fe (300mL)
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MRI of GI Tract

Used for usually upper GI, limited utility for lower GI/retroperitoneal region

600 mL PO at 300 mL/15 min

No more than 900 mL

Administration

Fast 4 hr before taking

<16 yo: safety/efficacy not established

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Warnings

Contraindications

Hypersensitivity

GI perforation or obstruction

Cautions

Hiatal hernia, GERD, nausea/vomiting, abd pain, pts on specific fluid intake, iron overload d/o (eg, hemochromatosis, hemosiderosis, frequent transfusions)

May cause nausea, vomiting, diarrhea, abd cramps

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Pregnancy & Lactation

Pregnancy Category: B

Lactation: iron enters breast milk, not known about other components; use caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Absorption: iron is absorbed (depends on iron stores); silicone not known

Excretion: feces

Mechanism of Action

Superparamagnetic iron oxide/silicone containing polymer

Fills stomach & small intestine 30-45 min postingestion

Passes thru large intestine 4-7 hr postingestion

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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  • View the formulary and any restrictions for each plan.
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  • Compare formulary status to other drugs in the same class.
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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