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glycerin (OTC)Brand and Other Names:

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

suppositories

  • 1.2g
  • 2.1g
more...

Constipation

2-3 g suppository, retain 15 min, PRN constipation OR

5-15 mL of rectal solution as an enema

Directions for liquid: insert stem with tip pointing toward navel, squeeze unit until empty, then remove

Dosage Forms & Strengths

suppositories

  • 1.2g
  • 2.1g
more...

Constipation

Neonate (<28 days)

  • 0.5 mL/kg q12-24hr PR PRN as an enema

<6 years

  • 1-1.7 g suppository, retain 15 min, PRN constipation OR
  • 2-5 mL of rectal solution as an enema

≥6 years

  • 2-3 g suppository, retain 15 min, PRN constipation OR
  • 5-15 mL of rectal solution as an enema
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Adverse Effects

Frequency Not Defined

Excessive bowel activity

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Warnings

Contraindications

GI obstruction, severe impaction

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: not known whether excreted in breast milk; no risks shown to nursing infants

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Onset: 15-30 min

Mechanism of Action

Hyperosmotic agent

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