acetaminophen/aspirin (OTC)Brand and Other Names:Goody's Powder Back & Body Pain, Excedrin Back & Body

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

acetaminophen/aspirin

oral powder (Goody's Powder Back & Body Pain)

  • 325mg/500 mg

caplet (Excedrin Back & Body)

  • 250mg/250mg
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Analgesia/Fever

Indicated to relieve minor pain caused by headache, muscular aches, fever, minor arthritis pain, and colds

Goody's Powder Back & Body Pain: 1 powder on tongue (or mixed in water or other liquid) PO q6hr; not to exceed 4 powders/24 hr

Excedrin Back & Body: 2 caplet PO q6hr; not to exceed 8 caplets/24 hr

Dosage Forms & Strengths

acetaminophen/aspirin

oral powder (Goody's Powder Back & Body Pain)

  • 325mg/500 mg

caplet (Excedrin Back & Body)

  • 250mg/250mg
more...

Analgesia/Fever

Indicated to relieve minor pain caused by headache, muscular aches, fever, minor arthritis pain, and colds

<12 years

  • Safety and efficacy not established

>12 years

  • Goody's Powder Back & Body Pain: 1 powder on tongue (or mixed in water or other liquid) PO q6hr; not to exceed 4 powders/24 hr
  • Excedrin Back & Body: 2 caplet PO q6hr; not to exceed 8 caplets/24 hr
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Interactions

Interaction Checker

acetaminophen/aspirin and

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Acetaminophen

            • Angioedema, laryngeal edema
            • Pruritic maculopapular rash, urticaria
            • Agranulocytosis, leukopenia, neutropenia, pancytopenia, thrombocytopenia, thrombocytopenic purpura
            • Hepatotoxicity
            • May increase uric acid, chloride, glucose
            • May decrease sodium, calcium, bicarbonate
            • Anaphylactoid reaction

            Aspirin

            • Rash, urticaria
            • Dyspepsia, heartburn, nausea, stomach pain, vomiting
            • Tinnitus (high or chronic dose)
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            Warnings

            Contraindications

            Hypersensitivity

            Hepatitis or severe hepatic/renal impairment

            Cautions

            Contains aspirin; children and adolescents should not use for symptoms of viral infections (eg, chickenpox, influenza) due to risk for Reye syndrome

            Hepatic impairment or consumption of 3 or more alcoholic beverages/day may increase risk for liver damage (associated with acetaminophen) or GI bleeding (associated with magnesium salicylate)

            Do not take with other products that contain acetaminophen due to risk of additive toxicity/overdose

            Avoid with active peptic ulcer disease

            Avoid in severe renal impairment (ie, CrCl <10 mL/min)

            Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash

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            Pregnancy & Lactation

            Pregnancy Category: D; avoid aspirin (NSAIDs) during pregnancy, particularly in third trimester because of risk for premature closure of the ductus arteriosus

            Lactation: Excreted in breast milk

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Acetaminophen: Inhibits prostaglandin synthesis in CNS and may block peripheral pain impulse generation; acts on hypothalamus as antipyretic

            Aspirin: Acts on hypothalamus to produce antipyresis; anti-inflammatory properties attributed to prostaglandin synthetase inhibition resulting in decreased formation of thromboxane A2

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