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griseofulvin (Rx)Brand and Other Names:Grifulvin V, Gris-PEG

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral suspension, microsize

  • 125mg/5mL

tablet, microsize

  • 500mg (Grifulvin V)

tablet, ultramicrosize

  • 125mg (Gris-PEG)
  • 250mg (Gris-PEG)
more...

Tinea Infection

Infections affecting skin, body, hair/beard, or nails

Microsize

  • Tinea corporis, cruris, or capitis: 500 mg/day PO
  • Tinea pedis or unguium: 1000 mg/day PO as single daily dose or divided q12hr

Ultramicrosize

  • Tinea corporis, cruris, or capitis: 375 mg/day PO
  • Tinea pedis or unguium: 250 mg PO q8hr

Treatment duration

  • Dependent on infection site
  • Tinea corporis: 2-4 weeks
  • Tinea capitis: 4-6 weeks; may be up to 8-12 weeks
  • Tinea pedis: 4-8 weeks
  • Tinea unguium: 4-6 months

Dosing considerations

  • Absorption increased with fatty meals

Dosage Forms & Strengths

oral suspension, microsize

  • 125mg/5mL

tablet, microsize

  • 500mg (Grifulvin V)

tablet, ultramicrosize

  • 125mg (Gris-PEG)
  • 250mg (Bris-PEG)
more...

Tinea Infection

Infections affecting skin, body, hair/beard, or nails

<2 years old: Safety and efficacy not established

Microsize

  • 11 mg/kg/day PO as single dose or divided q12hr  
  • 13.6-22.7 kg (30-50 lb): 125-250 mg/day
  • >22.7 kg (>50 lb): 250-500 mg/day
  • Off-label: 10-20 mg/kg/day PO divided q12hr

Ultramicrosize

  • 7.3 mg/kg/day PO
  • 13.6-22.7 kg (30-50 lb): 82.5-165 mg/day
  • >22.7 kg (>50 lb): 165-330 mg/day
  • Off-label: 5-15 mg/kg/day PO divided q12hr; not to exceed 750 mg/day

Treatment duration

  • Dependent on infection site
  • Tinea corporis: 2-4 weeks
  • Tinea capitis: 4-6 weeks; may be up to 8-12 weeks
  • Tinea pedis: 4-8 weeks
  • Tinea unguium: 4-6 months

Dosing considerations

  • Absorption increased with fatty meals
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Interactions

Interaction Checker

griseofulvin and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Rash (most common)

            Urticaria (most common)

            Headache

            Fatigue

            Dizziness

            Insomnia

            Mental confusion

            Photosensitivity

            Nausea

            Vomiting

            Epigastric distress

            Diarrhea

            GI bleeding

            Leukopenia

            Hepatotoxicity

            Proteinuria

            Nephrosis

            Oral thrush

            Angioneurotic edema (rare)

            Drug-induced lupuslike syndrome (rare)

            Menstrual irregularities (rare)

            Paresthesia (rare)

            Postmarketing Reports

            Severe skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis) and erythema multiforme

            Liver toxicity

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            Warnings

            Contraindications

            Hypersensitivity

            Porphyria

            Hepatocellular failure

            Pregnancy

            Cautions

            Severe skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis) and erythema multiforme reported, some resulting in hospitalization or death; discontinue if severe skin reaction occurs

            Elevations in AST, ALT, bilirubin, and jaundice reported, some resulting in hospitalization or death; discontinue if jaundice occurs

            Patients on prolonged therapy with any potent medication should be under close observation; periodic monitoring of organ system function, including renal, hepatic and hematopoietic, should be done

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            Pregnancy & Lactation

            Pregnancy category: X; no adequate and well-controlled studies in pregnant women, but animal studies have shown embryotoxic and teratogenic effects

            Lactation: Excretion in milk unknown; avoid use because of potential tumorigenicity

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Fungistatic; deposited in keratin precursor cells and is tightly bound to new keratin, and this increases resistance to fungal invasion

            Absorption

            Absorption of ultramicrosize griseofulvin absorption is almost complete; absorption of microsize griseofulvin is variable (25-70% of oral dose); enhanced by ingestion of fatty meal (GI absorption of ultramicrosize is 1.5 times that of microsize)

            Distribution

            Drug crosses placenta

            Metabolism

            Extensively metabolized by liver; hepatic CYP3A4 induced

            Elimination

            Half-life: 9-22 hr

            Excretion: Urine (<1% as unchanged drug), feces, perspiration

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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