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clotrimazole (Rx, OTC)Brand and Other Names:Gyne-Lotrimin-3 Combination Pack, Gyne-Lotrimin-3 Vaginal Cream, more...Gyne-Lotrimin-3 Vaginal Suppositories, Gyne-Lotrimin-7, Mycelex-7, Mycelex-7 Combination Pack, Mycelex vaginal

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

troche

  • 10mg

vaginal cream

  • 1%
  • 2%
more...

Candidiasis

Cream with applicator: If 1%, insert 1 applicatorful per day, preferably at bedtime, for 7 days; for 3 days if 2% vaginal cream used

Topical 1% cream: With finger, gently spread cream onto irritated area of vulva; apply qDay/q12hr for up to 7 days PRN to relieve external vulvar itching

Troches: 10 mg administered only as lozenge that must be slowly dissolved in mouth; administer 1 troche 5 times/day for 14 consecutive days

Pouchitis (Orphan)

Topical treatment of children and adults with pouchitis

Orphan indication sponsor

  • Atlantic Healthcare LTD; Maple House: Halsted, Essex CO9 4BB, UK

Dosage Forms & Strengths

troche

  • 10mg

vaginal cream

  • 1%
  • 2%
more...

Candidiasis

<3 years

  • Safety and efficacy not established

>3 years

  • Cream with applicator: If 1%, insert 1 applicatorful per day, preferably at bedtime, for 7 days; for 3 days if 2% vaginal cream used
  • Topical 1% cream: With finger, gently spread cream onto irritated area of vulva; apply qDay/q12hr for up to 7 days PRN to relieve external vulvar itching
  • Troches: 10 mg administered only as lozenge that must be slowly dissolved in mouth; administer 1 troche 5 times/day for 14 consecutive days

Pouchitis (Orphan)

Topical treatment of children and adults with pouchitis

Orphan indication sponsor

  • Atlantic Healthcare LTD; Maple House: Halsted, Essex CO9 4BB, UK
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Interactions

Interaction Checker

clotrimazole and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Abnl LFTs

            1-10%

            Nausea/vomiting (troches)

            Mild burning, irritation, stinging to skin or vaginal area (vaginal tabs/cream)

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            Warnings

            Contraindications

            Hypersensitivity

            Not for ophthalmic use

            Cautions

            Not for use in the treatment of systemic fungal infection

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            Pregnancy & Lactation

            Pregnancy category: B (vaginal cream); C (troches)

            Lactation: Excretion in milk unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Alters Candida cell membrane permeability; binds to phospholipids in fungal cell membrane, which alters cell wall permeability and results in the loss of intracellular elements; fungistatic and fungicidal

            Absorption

            Peak plasma time

            • Oral: Salivary levels occur within 3 hr following 30 min of dissolution time
            • Vaginal cream: High vaginal levels, 8-24 hr
            • Vaginal tablet: High vaginal levels, 1-2 d

            Elimination

            Excretion: Feces (as metabolites)

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            Images

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            Formulary

            FormularyPatient Discounts

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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