Brand and Other Names:Humalog Mix 50/50, Humalog Mix 50/50 Kwikpen, more...Humalog Mix 75/25, Humalog Mix 75/25 Kwikpen
- Classes: Antidiabetics, Insulins
Dosing & Uses
Dosage Forms & Strengths
insulin lispro protamine/insulin lispro
Combination rapid-onset (faster than regular insulin) and intermediate-acting insulins in fixed dose
Dose regimen varies among patients depending on metabolic needs; typical daily insulin requirements range between 0.5-1 unit/kg
Administer SC BID (ie, before breakfast and evening meal); each dose intended to cover 2 meals or a meal and snack
Inject SC into abdominal wall, thigh, or upper arm
Safety and efficacy not established
Frequency Not Defined
Local allergic reaction
During episodes of hypoglycemia
Never share pen between patients even it needle is changed
Suspension for SC use, do not administer IV
Administer within 15 minutes of meals (rapid onset and peak ~1 hr)
Rapid changes in serum glucose may induce symptoms of hypoglycemia
Early warning symptoms of hypoglycemia may be different or less pronounced under certain conditions (eg, long duration of diabetes, diabetic nerve disease, use of beta-blockers or intensified diabetes control)
Caution in conditions with decreased insulin requirements (eg, diarrhea, nausea, vomiting, malabsorption, hypothyroidism, renal impairment, hepatic impairment)
Caution in conditions with increased insulin requirements (eg, fever, hyperthyroidism, trauma, infection, surgery)
Thiazolidinediones are peroxisome proliferator-activated receptor (PPAR)-gamma agonists and can cause dose-related fluid retention, particularly when used in combination with insulin; fluid retention may lead to or exacerbate heart failure, monitor for signs and symptoms of heart failure and treat accordingly and consider discontinuing thiazolidinediones
Glucose monitoring recommended for all patients with diabetes
Do not mix with other insulins
Do not administer via insulin infusion pump
Pregnancy & Lactation
Pregnancy Category: B
Lactation: Unknown whether distributed in breast milk; compatible with breast feeding, but lactating women may require dosage adjustment; caution advised
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Bioavailability: SC, well absorbed (2-3 times faster than regular insulin)
Onset: <15 min
Peak Plasma Time: 30-90 min
Protein Bound: 0-9%; similar to regular human insulin
Metabolism: Liver >50%, kidney 30%, adipose tissue/muscle 20%
Vd: 0.26-0.36 L/kg
Mechanism of Action
Binds insulin receptors; activates mechanisms that lower blood glucose by facilitating cellular uptake of glucose into skeletal muscle and fat, simultaneously inhibits glucose output from liver
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