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paromomycin (Rx)Brand and Other Names:Humatin

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 250mg
more...

Intestinal Amebiasis (E. Histolytica)

25-35 mg/kg/day PO divided q6hr for 5-10 days 

Effective in acute and chronic but not extraintestinal

Hepatic Coma (Adjunctive)

4 g PO qDay in divided doses for 5-6 days

Diantomoeba Fragilis

20-30 mg/kg/day PO divided q8hr

Tapeworm (T. saginata/T. solium/D. latum/D. caninum)

11 mg/kg PO divided q15min for 4 doses

Dwarf Tapeworm

45 mg/kg/dose PO qDay for 5-7 days

Cutaneous Leishmaniasis (Orphan)

Treatment of cutaneous leishmaniasis (Old World and New World)

Sponsor

  • The Surgeon General, Dept. of the Army; USAMRMC; 504 Scott Street; Ft. Detrick; MD

Dosage Forms & Strengths

capsule

  • 250mg
more...

E. Histolytica

25-35 mg/kg/day divided q8hr PO for 7 days OR

750 mg/m²/day divided q6hr PO for 5 days

Dientamoeba Fragilis

25-30 mg/kg/day PO divided q8hr for 7 days 

Intestinal Amebiasis

25-35 mg/kg/day PO divided q8hr for 5-10 days 

Tapeworm (Hymenolepis nana)

45 mg/kg PO qDay for 5-7 days 

Tapeworm (T. saginata/T. solium/D. latum/D. caninum)

11 mg/kg PO divided q15min for 4 doses 

Dwarf Tapeworm

45 mg/kg/dose PO qDay for 5-7 days

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Interactions

Interaction Checker

paromomycin and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Diarrhea

            Abdominal cramps

            Nausea

            Vomiting

            Heartburn

            <1%

            Headache

            Vertigo

            Exanthema

            Rash

            Pruritus

            Steatorrhea

            Secondary enterocolitis

            Eosinophilia

            Ototoxicity

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            Warnings

            Contraindications

            Hypersensitivity, intestinal obstruction

            Cautions

            Prolonged treatment may result in fungal or bacterial superinfection

            Caution in renal impairment or patients with ulcerative bowel lesions

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: does not enter breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Aminoglycoside; interferes with bacterial protein synthesis by binding to 30S ribosomal subunits; has antibacterial against pathogenic organisms in the GI tract

            Pharmacokinetics

            Absorption: Poor

            Excretion: Feces (100% as unchanged drug)

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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