diatrizoate (Rx)

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Brand and Other Names:Cystografin

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

uretral solution

  • 30%
  • 18% (dilute)
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Retrograde Cystourethrography

Instill 25-300 mL into bladder depending on age of patient and degree of bladder irritability; amounts >300 mL may be used if bladder capacity allows; best results obtained when the bladder is filled with the contrast agent

Administration

After sterile catheterization, the bladder should be filled to capacity using suitable sterile administration set; avoid using excessive pressure; presence of bladder discomfort or reflux and/or spontaneous voiding usually indicates bladder is full

Dosage Forms & Strengths

uretral solution

  • 30%
  • 18% (dilute)
more...

Retrograde Cystourethrography

Instill 25-300 mL into bladder depending on age of patient and degree of bladder irritability; amounts >300 mL may be used if bladder capacity allows; best results obtained when the bladder is filled with the contrast agent

Administration

After sterile catheterization, the bladder should be filled to capacity using suitable sterile administration set; avoid using excessive pressure; presence of bladder discomfort or reflux and/or spontaneous voiding usually indicates bladder is full

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Adverse Effects

Frequency Not Defined

Hypothyroidism or transient thyroid suppression

With intravasation of drug

  • Anaphylactoid reactions manifested as edema of the face and glottis, respiratory distress, confusion or shock that can be fatal
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Warnings

Contraindications

Hypersensitivity to diatrizoate

Intravascular or intrathecal use

Cautions

Personal or family history of bronchial asthma, significant allergies, or previous reactions to contrast agents

Iodine sensitivity

Use intravascular techniques that minimize risk for extravasation

Use caution in hepatic impairment, heart failure, hypertension, multiple myeloma, hyperthyroidism, pheochromocytoma, renal impairment, sickle cell disease, subarachnoid hemorrhage, and thromboembolism

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Excreted in breast milk, use caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Provides contrast enhancement of the bladder

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Images

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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