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rabies immune globulin, human (RIG) (Rx)Brand and Other Names:HyperRAB, HyperRAB S/D, more...Imogam, Imogam Rabies HT, Imovax Rabies, RIG

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 150 International Units/mL (2mL vial)
  • 150 International Units/mL (10mL vial)
more...

Rabies, Postexposure Prophylaxis

20 International Unit/kg, infiltrate locally around bite 

If full dose infiltration not possible, give rest IM in gluteal or lateral thigh muscle

Administration

Because of injury risk to sciatic nerve, avoid central gluteal region; administer only in upper, outer quadrant

Always administer in conjunction with rabies vaccine (HDCV)

Preferably give concomitantly with vaccine but may be given thru 7th day after first dose of vaccine

Avoid repeated dose once vaccine treatment has started

Other Information

Give with 1st dose of vaccine as soon as possible post-exposure

Dosage Forms & Strengths

injectable solution

  • 150 International Units/mL (2mL vial)
  • 150 International Units/mL (10mL vial)
more...

Same as adult dosing; 20 International Unit/kg, infiltrate locally around bite

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Interactions

Interaction Checker

rabies immune globulin, human (RIG) and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Injection site pain

            N/V

            Fever

            Lethargy

            Chest tightness

            Rash

            Headache

            Anaphylaxis

            Angioneurotic edema

            Nephrotic syndrome (rare)

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            Warnings

            Contraindications

            None

            Cautions

            Thrombocytopenia, bleeding disorders, or prior allergic reactions to immune globulins

            Avoid live vaccinations for 3 mth

            Do NOT give IV

            Discard unused portions

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: no adverse events reported; may be excreted in breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Half-Life: 21 d

            Peak Plasma Time: 2-13 d

            Mechanism of Action

            Human immune globulins from donors

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            Images

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            Formulary

            FormularyPatient Discounts

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
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            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
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            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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