tetanus immune globulin (TIG) (Rx)

Brand and Other Names:Hyper Tet, HyperTET S/D, more...TIG
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

powder for injection

  • 250 units
more...

Tetanus

Prophylaxis: 250 Units IM (single dose)

Active tetanus: 3000-6000 Units IM

Clean minor wound

  • # doses unknown or 0-2 doses; toxoid only
  • >3 doses; toxoid if >10 years ago

All other wounds

  • # doses unknown or 0-1 doses; toxoid plus IG
  • 2 doses; toxoid, but no IG if wound <24 hours old
  • >3 doses; toxoid if >5 years ago, and no IG

Dosage Forms & Strengths

powder for injection

  • 250 units
more...

Tetanus Prophylaxis

<7 years old: 4 Unit/kg or 250 Units IM 

>7 years old: 250 Units IM (single dose)

Tetanus Treatment

3000-6000 Units IM

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Interactions

Interaction Checker

and tetanus immune globulin (TIG)

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Urticaria

            Injection site pain

            N/V

            Fever

            Lethargy

            Chest tightness

            Anaphylaxis

            Angioneurotic edema

            Nephrotic syndrome (rare)

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            Warnings

            Contraindications

            Hypersensitivity to gamma globulin, IgA, thimerosal

            Cautions

            Thrombocytopenia or coagulation disorders may contraindicate IM injection

            Made from human plasma, small risk of viral transmission through administration

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known if excreted in breast milk, no adverse effects reported

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Human immune globulins from donors

            Pharmacokinetics

            Half-life: 23 days

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            Images

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            Formulary

            FormularyPatient Discounts

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
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            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
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            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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