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iron dextran complex (Rx)Brand and Other Names:INFeD, Dexferrum

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 50mg (Fe)/mL
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Iron-deficiency Anemia

25-100 mg IV or deep IM qDay PRN

Not to exceed 100 mg (2 mL)/day

Iron deficiency: Dose = 0.0442(Desired Hgb - Observed Hgb) x Lean BW(kg) + (0.26 × Lean BW)

Blood loss: total iron dose in mg = blood loss (mL) x HCT

Dosage Forms & Strengths

injectable solution

  • 50mg (Fe)/mL
more...

Iron-deficiency Anemia

5-15 kg

Not to be given in first 4 months of life

Dose = 0.0442(Desired Hgb - Observed Hgb) x BW(kg) + (0.26 × BW)

Desired hemoglobin usually 12 g/dL

>15 kg: 0.0442(Desired Hgb - Observed Hgb) x Lean BW(kg) + (0.26 × Lean BW)

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Interactions

Interaction Checker

iron dextran complex and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Abdominal pain

            Diarrhea

            Nausea

            Vomiting

            Arthralgia

            Arthritis

            Soreness

            Inflammation

            Pruritus

            Rash

            Urticaria

            Brown discoloration of skin

            Frequency Not Defined

            Seizure

            Chest pain

            Hypotensive shock

            Dyspnea

            Respiratory arrest

            Leukocytosis

            Anaphylaxis

            Hematuria

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            Warnings

            Black Box Warnings

            Anaphylactic type reactions, sometimes fatal, have occurred with parenteral use of this product. Reserve for use only in patients with laboratory-confirmed iron deficiency who are unable to take oral iron.

            Contraindications

            Hypersensitivity

            Anemia not associated with iron deficiency

            Acute phase of infectious renal disease

            Cautions

            Use caution in rheumatoid arthritis, HIV+ patients, history of allergies, history of asthma, severe hepatic impairment, preexisting cardiovascular disease

            May increase pathogenicity of certain microorganisms

            May induce hemosiderosis if used for non-iron-deficiency anemia

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: traces excreted in breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin

            Pharmacokinetics

            Half-Life: 6 hr

            Onset: 7-9 days (serum ferritin peak)

            Peak Plasma Time: 10 days

            Absorption: Within 72 hr (IM)

            Excretion: Minimal through urine and feces

            Dialyzable: No

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            Administration

            IV Preparation

            Standard diluent: dose/250-1000 mL NS

            Minimum volume: 250 mL NS

            IV/IM Administration

            IM: use z-track technique for IM administration (deep into upper outer quadrant of buttock)

            IV may be administered bolus at <50 mg/min or diluted in 250-1000 mL NS & infused over 1-6 hr

            Infuse initial 25 mL slowly, observe for allergic reactions

            Have epinephrine nearby

            Storage

            Store at room temp

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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