tinzaparin (Discontinued)Brand and Other Names:Innohep

 
 
 

Dosing & Uses

AdultPediatric

Product discontinued in the United States

Safety and efficacy not established

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Interactions

Interaction Checker

tinzaparin and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Erythema (16%)

            Pain, local (16%)

            Irritation, local (16%)

            Increased LFT's, asymptomatic (9-13%)

            1-10%

            Urinary tract infection (4%)

            Pulmonary embolism (2%)

            Chest pain (2%)

            Epistaxis (2%)

            Headache (2%)

            Nausea (2%)

            Hemorrhage (1.5%)

            Back pain (1.5%)

            Fever (1.5%)

            General pain (1.5%)

            Constipation (1%)

            Rash (1%)

            Dyspnea (1%)

            Vomiting (1%)

            Hhematuria (1%)

            Thrombocytopenia (1%)

            <1%

            Bleeding, major

            Thrombocytopenia ,severe

            Diarrhea

            Granulocytopenic disorder (rare)

            Hematoma, spinal/epidural (rare)

            Pancytopenia (rare)

            Priapism (rare)

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            Warnings

            Black Box Warnings

            Epidural or spinal hematomas may occur in patients anticoagulated with LMWH or heparinoids who receive neuraxial (epidural/spinal) anesthesia or spinal puncture

            These hematomas may result in long-term or permanent paralysis

            Patients should be frequently monitored for signs and symptoms of neurologic impairment

            If neurological compromise is noted, urgent treatment is necessary

            Physicians should consider the benefits versus risk before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis

            Factors increasing risk of epidural or spinal hematomas

            • Indwelling epidural catheters
            • Concomitant use of other drugs that affect hemostasis (eg, NSAIDs, platelet inhibitors, other anticoagulants)
            • History of traumatic or repeated epidural or spinal punctures
            • History of spinal deformity or spinal surgery

            Contraindications

            Active major bleeding, heparin-induced thrombocytopenia

            Hypersensitivity to heparin, sulfites, benzyl alcohol, pork products

            Cautions

            May increase risk for death compared to UHF when used to treat elderly patients with renal insufficiency

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            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: not known if excreted in breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Half-life: 3-4 hr

            Peak plasma time: 4-5 hr

            Peak plasma concentration: 0.87 IU/mL

            Bioavailability: 87%

            Vd: 3.1-5.0 L

            Clearance: 1.7 L/hr

            Excretion: urine

            Mechanism of Action

            LMW heparin, anti-Factor Xa & IIa

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