Vinpocetine (Herbs/Suppl)Brand and Other Names:Intelectol

 
 
 

Suggested Dosing

Cognitive impairment due to vascular disease

5-10 mg PO TID

Take with food

Next

Suggested Uses

Increases cerebral blood flow and metabolism, anticonvulsation, cognition enhancement, neuroprotection, antioxidation, cerebral vasodilation

Efficacy

Some clinical studies show prophylactic effects in ischemic stroke & cognitive improvement

Sold as a legal pharmaceutical product in Japan, Europe, & Mexico

Not beneficial in Alzheimer's disease

Previous
Next

Interactions

Interaction Checker

Vinpocetine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            Frequency Not Defined

            Nausea

            Dizziness

            Insomnia

            Drowsiness

            Dry mouth

            Transient hypotension

            Transient tachycardia

            Pressure-type headache

            Facial flushing

            Prolonged use: slight reductions in both systolic & diastolic blood pressure & blood glucose

            Previous
            Next

            Warnings

            Contraindications

            Hypersensitivity to vinpocetine or other vinca alkaloids

            Pts in incomplete homeostasis after cerebral haemorrhage

            Pregnancy, lactation

            <18 years old

            Cautions

            Hemophilia, heart problems or low blood pressure

            Monitor INR in patients on warfarin

            Previous
            Next

            Pregnancy & Lactation

            Pregnancy Category: avoid

            Lactation: avoid

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Peak Plasma Time: 1-1.5 hr

            Half-Life, elimination: 1-2 hr

            Absorption: 60% with food, 7% without

            Metabolism: extensively to inactive apovincaminic acid in liver

            Excretion: urine

            Mechanism of Action

            Shown to inhibit cGMP phosphodiesterase that has may result in increased cerebral blood flow

            Reported to have calcium-channel blocker, voltage-gated sodium channel blocker, & acetylcholine release activities

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.