Brand and Other Names:Iopidine
- Classes: Antiglaucoma, Alpha Agonists
Dosing & Uses
Dosage Forms & Strengths
Inhibition of Perioperative Intraocular Pressure (IOP) Increase
1 gtt of a 1% solution onto the eye undergoing surgery 1 hour before surgery & repeated immediately upon completion of surgery
1-2 gtt of a 0.5% solution in the affected eye(s) q8hr
Safety & efficacy not established
Serious - Use Alternative
Significant - Monitor Closely
Varies with strength & application
Ocular adverse effects:
Frequency Not Defined
Dry eyeForeign body sensationLid edema
Edema, conjunctival follicles
Lid margin crusting
Nonocular adverse effects:
Frequency Not Defined
Hypersensitivity to apraclonidine, clonidine, or components
Within 14 days of MAO inhibitors administration
Caution in active cardiac disease, including HTN, coronary insufficiency, recent MI, cerebrovascular disease, chronic renal failure, Raynaud's disease, thromboangiitis obliterans, history of vasovagal attacks
Discontinue if ocular allergic-type reactions develop
Monitor closely if excessive IOP reduction
May impair mental alertness & ability to perform hazardous activities
Pregnancy & Lactation
Pregnancy Category: C
Lactation: It is not known if Iopidine is excreted in milk. Decision should be made to discontinue nursing temporarily for the one day on which Iopidine is used.
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Alpha-1 & alpha-2 adrenergic receptor agonist; may reduce acqueous humor formation
Peak Plasma Time: 3-5 hr (reduction in intraocular pressure)
Peak Plasma Concentration (0.5% admin): 0.9 ng/mL
Half-Life (0.5% admin): 8 hr
Onset: 1 hr
Abslorption: Systemically absorbed
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|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
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|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
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