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apraclonidine (Rx)Brand and Other Names:Iopidine

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 0.5%
  • 1%
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Inhibition of Perioperative Intraocular Pressure (IOP) Increase

1 gtt of a 1% solution onto the eye undergoing surgery 1 hour before surgery & repeated immediately upon completion of surgery

Glaucoma

1-2 gtt of a 0.5% solution in the affected eye(s) q8hr

Safety & efficacy not established

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Interactions

Interaction Checker

apraclonidine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Varies with strength & application

            Ocular adverse effects:

            Frequency Not Defined

            Discomfort

            Hyperemia

            Pruritus

            Blanching

            Blurred vision

            Conjunctivitis

            Discharge

            Dry eyeForeign body sensationLid edema

            Tearing

            Abnormal vision

            Blepharitis, blepharo

            Conjunctivitis

            Conjunctival

            Edema, conjunctival follicles

            Corneal erosion

            Corneal infiltrate

            Corneal staining

            EdemaIrritation

            Keratitis

            Keratopathy

            Lid disorder

            Lid erythema

            Lid margin crusting

            Lid retraction

            Lid scales

            Pain

            Photophobia

            Nonocular adverse effects:

            Frequency Not Defined

            Dry mouth

            Arrhythmia

            Facial edema

            Abnormal coordination

            Asthenia

            Depression

            Dizziness

            Headache

            Insomnia

            Malaise

            Nervousness

            Paresthesia

            Parosmia

            Peripheral edema

            Somnolence

            Contact dermatitis,

            Dry nose

            Constipation

            Nausea

            Taste perversion

            Myalgia

            Asthma

            Chest pain

            Dyspnea

            Pharyngitis

            Rhinitis

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            Warnings

            Contraindications

            Hypersensitivity to apraclonidine, clonidine, or components

            Within 14 days of MAO inhibitors administration

            Cautions

            Caution in active cardiac disease, including HTN, coronary insufficiency, recent MI, cerebrovascular disease, chronic renal failure, Raynaud's disease, thromboangiitis obliterans, history of vasovagal attacks

            Discontinue if ocular allergic-type reactions develop

            Monitor closely if excessive IOP reduction

            May impair mental alertness & ability to perform hazardous activities

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: It is not known if Iopidine is excreted in milk. Decision should be made to discontinue nursing temporarily for the one day on which Iopidine is used.

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Alpha-1 & alpha-2 adrenergic receptor agonist; may reduce acqueous humor formation

            Pharmacokinetics

            Peak Plasma Time: 3-5 hr (reduction in intraocular pressure)

            Peak Plasma Concentration (0.5% admin): 0.9 ng/mL

            Half-Life (0.5% admin): 8 hr

            Onset: 1 hr

            Abslorption: Systemically absorbed

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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