Mistletoe (Herbs/Suppl)

Brand and Other Names:iscador, viscum album
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Suggested Dosing

Hypertension

Crude fruit or herb to make tea

10 g/day

Cancer

No standard dose

Iscador: fermented mistletoe extracts

10 mg extract contains 750 ng lectin

IV/SC

  • 0.1 to 30 mg several times per week have been used

Solid Tumor

  • Intratumoral/SC/IV: preparations containing lectin 20,000 ng/mL or viscotoxins 100 mcg/mL have been used
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Suggested Uses

Cancer: adjunct to chemotherapy, hypertension

Efficacy

Reviewing 21 clinical studies, Horneber et al (Cochrane Database Syst Rev. 2008) concluded:

  • Evidence from RCTs to support anticancer effects of mistletoe is weak
  • Some evidence that mistletoe extracts may offer benefits on QOL measures during chemotherapy for breast cancer chemotherapy, but these results need replication
  • More high quality, independent clinical research is needed to truly assess the safety & effectiveness of mistletoe extracts
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Interactions

Interaction Checker

and Mistletoe

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Oral: N/V, hepatitis, hypotension, seizure, coma, death

            Parenteral: chills, HA, angina, orthostatic hypotension, allergic reaction

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            Warnings

            Contraindications

            Hypersensitivity, oral ingestion

            Cautions

            This is European mistletoe; do not confuse with American mistletoe (Phoradendron spp.)

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            Pregnancy & Lactation

            Pregnancy Category: N/A

            Lactation: N/A

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Lectins, alkaloids, viscotoxins: biological response modifiers, cytotoxic agents

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