Crude fruit or herb to make tea
No standard dose
Iscador: fermented mistletoe extracts
10 mg extract contains 750 ng lectin
- 0.1 to 30 mg several times per week have been used
- Intratumoral/SC/IV: preparations containing lectin 20,000 ng/mL or viscotoxins 100 mcg/mL have been used
Cancer: adjunct to chemotherapy, hypertension
Reviewing 21 clinical studies, Horneber et al (Cochrane Database Syst Rev. 2008) concluded:
- Evidence from RCTs to support anticancer effects of mistletoe is weak
- Some evidence that mistletoe extracts may offer benefits on QOL measures during chemotherapy for breast cancer chemotherapy, but these results need replication
- More high quality, independent clinical research is needed to truly assess the safety & effectiveness of mistletoe extracts
Serious - Use Alternative
Significant - Monitor Closely
Oral: N/V, hepatitis, hypotension, seizure, coma, death
Parenteral: chills, HA, angina, orthostatic hypotension, allergic reaction
Hypersensitivity, oral ingestion
This is European mistletoe; do not confuse with American mistletoe (Phoradendron spp.)
Pregnancy & Lactation
Pregnancy Category: N/A
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Lectins, alkaloids, viscotoxins: biological response modifiers, cytotoxic agents