Brand and Other Names:isoflavones, daidzein, more...genistein, ipriflavone, ostivone, soy isoflavones
- Classes: Urology, Herbals
40 mg PO qD
Menopausal symptoms: 34-120 mg/d
Hypertension: 18 mg PO BID
Lung cancer prevention: 8.3 -83.2 mcg/d
200 mg PO TID
CrCl 40-80 mL/min
200 mg PO BID
CrCl <40 mL/min
200 mg PO qD
Menopausal vasomotor symptoms, osteoporosis
Decrease risk of breast cancer, CVD
Studies show reasonable efficacy for breast cancer, diabetes, osteoporosis prevention/treatment, hot flashes, CVD risk
Mixed results for cancer prevention
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Pregnancy & Lactation
Pregnancy Category: avoid use
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Partial estrogen receptor agonists; anti-estrogenic effects in premenopausal women, but weak estrogenic effects in postmenopausal women
May stimulate osteoblastic activity
Incr sex hormone binding globulin (SHBG) levels; antioxidant activity