Phytoestrogens (Herbs/Suppl)

Brand and Other Names:isoflavones, daidzein, more...genistein, ipriflavone, ostivone, soy isoflavones
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Suggested Dosing

Isoflavones

40 mg PO qD

Menopausal symptoms: 34-120 mg/d

Hypertension: 18 mg PO BID

Lung cancer prevention: 8.3 -83.2 mcg/d

Ipriflavone

200 mg PO TID

CrCl 40-80 mL/min

200 mg PO BID

CrCl <40 mL/min

200 mg PO qD

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Suggested Uses

Menopausal vasomotor symptoms, osteoporosis

Decrease risk of breast cancer, CVD

Efficacy

Studies show reasonable efficacy for breast cancer, diabetes, osteoporosis prevention/treatment, hot flashes, CVD risk

Mixed results for cancer prevention

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Interactions

Interaction Checker

and Phytoestrogens

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Allergic reaction

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            Warnings

            Contraindications

            Pregnancy

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            Pregnancy & Lactation

            Pregnancy Category: avoid use

            Lactation: N/A

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Partial estrogen receptor agonists; anti-estrogenic effects in premenopausal women, but weak estrogenic effects in postmenopausal women

            May stimulate osteoblastic activity

            Incr sex hormone binding globulin (SHBG) levels; antioxidant activity

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