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scopolamine ophthalmic (Discontinued)Brand and Other Names:Isopto Hyoscine

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 0.25%
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Iridocyclitis

Discontinued by manufacturer (12/18/2012)

Indicated preoperatively and/or postoperatively for iridocyclitis

Instill 1-2 gtt into eye(s) up to 4 times/day

Mydriasis & Cycloplegia

Indicated in diagnostic procedures

Instill 1-2 gtt into eye(s) 1 hr before refracting

Administration

Avoid excessive absorption by compressing lacrimal sac with fingers for 2-3 minutes after instillation

Safety and efficacy not established

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Adverse Effects

Frequency Not Defined

Local irritation

Eczematoid dermatitis

Excessive use may cause systemic effects (eg, somnolence, drowsiness, visual hallucinations)

Xerostomia

Exudate

Photophobia

Vascular congestion

Blurred vision

Edema

Follicular conjunctivitis

Increased intraocular pressure

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Warnings

Contraindications

Hypersensitivity

Primary glaucoma or narrow anterior chamber angle

Cautions

Do not touch dropper to avoid contamination; contaminated multi-dose solutions may cause bacterial keratitis

Estimate depth anterior chamber angle to avoid inducing angle-closure glaucoma

Initial visual disturbances and pain within the eye are reasons for discontinuation

Ophthalmic use only

Remove contact lenses prior to administration and wait 15 min before reinserting

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Distributed in breast milk; American Academy of Pediatrics classifies scopolamine as compatible with breast-feeding

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Elicits anticholinergic effects at parasympathetic sites in sphincter muscle of the iris and accommodative muscle of the ciliary body; prevents accomodation and dilates pupils

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Images

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