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ecallantide (Rx)Brand and Other Names:Kalbitor

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 10mg/mL per single-use vial
more...

Hereditary Angioedema (Acute Attacks)

30 mg (3 mL) SC administered in 3 separate 10 mg (1 mL) injections

If attack persists, may administer an additional dose of 30 mg within 24 hr

Dosage Forms & Strengths

injectable solution

  • 10mg/mL per single-use vial
more...

Hereditary Angioedema (Acute Attacks)

<12 years: Safety and efficacy not established

≥12 years: As adults; 30 mg (3 mL) SC administered in 3 separate 10 mg (1 mL) injections

If attack persists, may administer additional 30 mg dose within 24 hr

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Interactions

Interaction Checker

ecallantide and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Headache (16.1%)

            Nausea (12.9%)

            Fatigue (11.8%)

            Diarrhea (10.6%)

            1-10% (selected)

            Upper respiratory tract infection (8.2%)

            Nasopharyngitis (5.9%)

            Vomiting (5.5%)

            Pruritus (5.1%)

            Upper abdominal pain (5.1%)

            Pyrexia (4.7%)

            Anaphylaxis (3.9%)

            Injection site reactions

            Rash

            Urticaria

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            Warnings

            Boxed Warning

            Anaphylaxis has been reported in 3.9% of treated patients

            Because of risk for anaphylaxis, administered by healthcare professional only with medical support

            Healthcare professionals should be aware of similarity of symptoms between anaphylaxis and angioedema

            Do not administer to patient with known hypersensitivity to ecallantide

            Symptoms have included chest discomfort, flushing, pharyngeal edema, pruritus, rhinorrhea, sneezing, nasal congestion, throat irritation, urticaria, wheezing, and hypotension

            Pruritus, rash, and urticaria may also indicate hypersensitivity

            These reactions occurred within the first hour after dosing

            Contraindications

            Hypersensitivity

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Human plasma kallikrein inhibitor, thereby reducing conversion of kininogen to bradykinin; bradykinin production may contribute to increased vascular permeability and angioedema experienced in HAE

            Pharmacokinetics

            Half-life: 2 hr

            Vd: 26.4 L

            Peak plasma time: 2-3 hr  

            Peak plasma concentration: 586 +/- 106 ng/mL

            Clearance:  153 mL/min

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            Administration

            Instructions

            Because of risk for anaphylaxis, administered by healthcare professional only with medical support

            Inject in thigh, abdomen, or upper arm

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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