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potassium bicarbonate/potassium citrate (Rx)Brand and Other Names:Klor-Con/EF, K-Lyte, more...K-Lyte DS

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

Doses expressed as mEq of potassium

tablet for oral solution

  • 10 mEq
  • 20 mEq
  • 25 mEq
more...

Daily Requirements

40-100 mEq/day or 1-2 mEq/kg/day

Hypokalemia

Prevention: 10-80 mEq/day PO qDay or divided qid

Treatment: 40–100 mEq/day dissolved in at least 4 ounces (per tablet) cold water PO divided bid/qid

Divide doses so that single doses are not > 25 mEq to avoid GI adverse effects

Renal Impairment

Use in patients with chronic renal disease or any condition impairing potassium excretion requires careful monitoring

Hepatic Impairment

No dosage adjustments listed by the manufacturer

Dose Considerations

If hypokalemia is result of diuretic therapy, consider lowering diuretic dose

Proper dilution lessens the possibility of gastrointestinal irritation

Safety and efficacy not established

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Interactions

Interaction Checker

potassium bicarbonate/potassium citrate and

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     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Hyperkalemia

            Nausea

            Vomiting

            Flatulence

            Abdominal pain or discomfort

            Diarrhea

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            Warnings

            Contraindications

            Patients with hyperkalemia

            Hypersensitivity to any component of product

            Concomitant use with potassium sparring diuretics or potassium supplements

            Cautions

            Hyperkalemia may complicate chronic renal failure, systemic acidosis, acute dehydration, extensive tissue breakdown as in severe burns, adrenal insufficiency or administration of potassium-sparing diuretics

            Use caution in patients with acid/base alterations

            Use caution in patients with cardiovascular disease

            Use alkalinizing potassium salts in patients with hypokalemia that have metabolic acidosis concomitantly

            Digitalized patients may be more susceptible to potentially life-threatening cardiac effects

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Unknown whether distributed in breast milk, caution advised

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Potassium depletion occurs when rate of loss through renal excretion and/or GI tract exceeds intake

            Supplementation with potassium-containing products may alleviate depletion

            Potassium plays essential role in the conduction of nerve impulses in the heart, brain, and skeletal muscle; plays a role in contraction of cardiac, skeletal, and smooth muscles

            Pharmacokinetics

            Absorption: Well absorbed in upper GI tract

            Distribution: Cells (via active transport from extracellular fluid)

            Excretion: Urine (primarily), skin, and feces

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            Formulary

            FormularyPatient Discounts

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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