Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

arginine (Rx)Brand and Other Names:L-arginine, RGene-10

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

intravenous solution

  • 30g/300mL
more...

Pituitary Stimulation

Used as a diagnostic pituitary stimulant to measure human growth hormone (hGH) reserve for conditions such as panhypopituitarism, pituitary dwarfism, chromophobe adenoma, postsurgical craniopharyngioma, hypophysectomy, pituitary trauma, acromegaly, gigantism, and problems of growth and stature

300 mL (30 g) IV infused over 30 minutes

Test procedure

  • Schedule AM
  • Fast overnight and continue through test period
  • Place patient on bed rest for at least 30 minutes before infusion begins
  • Take sample draws at -30, 0, 30, 60, 90, 120 and 150 minutes
  • To confirm negative response to insulin hypoglycemia test allow 1 day waiting period after insulin test patients may not respond during first test, second test may be performed after 1 day waiting period

Hemoglobinopathies & Thalassemia (Orphan)

Indicated for treatment of beta-hemoglobinopathies and beta-thalassemia

Orphan indication sponsor

  • Perrine, Susan P, MD; Boston University, Cancer Research Center; Boston, MA 02118

Dosage Forms & Strengths

intranvenous solution

  • 30g/300mL
more...

Pituitary Stimulation

Used as a diagnostic pituitary stimulant to measure human growth hormone (hGH) reserve for conditions such as panhypopituitarism, pituitary dwarfism, chromophobe adenoma, postsurgical craniopharyngioma, hypophysectomy, pituitary trauma, acromegaly, gigantism, and problems of growth and stature

0.5 g/kg IV infused over 30 minutes; not to exceed 30 g/dose

Test procedure

  • Schedule AM
  • Fast overnight and continue through test period
  • Place patient on bed rest for at least 30 minutes before infusion begins
  • Take sample draws at -30, 0, 30, 60, 90, 120 and 150 minutes
  • To confirm negative response to insulin hypoglycemia test allow 1 day waiting period after insulin test patients may not respond during first test, second test may be performed after 1 day waiting period
Next

Interactions

Interaction Checker

arginine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            1-10%

            Headache (3%)

            Flushing (3%)

            Nausea (3%)

            Vomiting (3%)

            Numbness (3%)

            Local venous irritation (3%)

            <1%

            Macular rash

            Swelling of hands and feet

            Hematuria

            Hyperkalemia

            Skin burn/necrosis

            Loss of consciousness

            Perioral tingling

            Previous
            Next

            Warnings

            Contraindications

            Hypersensitivity to product or components

            Cautions

            Hypersensitivity reactions, including anaphylaxis reported

            Confirm with 2nd test if diagnosis results show hGH deficiency; allow 1 day waiting period between tests

            Avoid overdosage in pediatric patients (risk of causing metabolic acidosis, cerebral edema, or death)

            Administer IV route only

            Electorlyte imbalances including hypophosphatemia, hyponatremia (following overdose) and acidosis, and hyperkalemia reported with arginine infusions; risk may increase in renal impairment, diabetes mellitus, and hepatic impairment

            Not intended for therapeutic use

            Use caution in patients with electrolyte imbalance

            Use caution in diabetes mellitus (may lead to life-threatening hyperkalemia)

            Tissue damage may occur with extravasation

            Avoid use in myocardial infarction

            Use caution in impaired renal function or electrolyte imbalance

            Previous
            Next

            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: Enters breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Induces rise of human growth hormone (HGH); patients with impaired pituitary function have lower or no increase in plasma concentration of growth hormone following arginine administration; used as test for pituitary function

            Pharmacokinetics

            Peak serum time: ~20-30 min (IV)

            Half-life: 0.7-1.3 hr

            Vd: ~33 L/kg following 30 g IV dose

            Previous
            Next

            Administration

            IV Preparation

            A special air-inletting, air-filtering set w/ bacterial air filter is required

            No airway needle is needed

            Remove metal seal and metal disc from bottle to expose rugger stopper

            Do not contaminate target site of stopper

            With shut-off clamp closed, remove sterility protector from spike of administration set and immediately insert set with quick trust into center of stopper with bottle upright on table (ie, push straight in, DO NOT twist)

            Invert bottle to establish fluid level in drip chamber and to check for vacuum by observing rising air bubbles

            Discard bottle if no vacuum or solution not clear

            Clear tubing of air and proceed with infusion

            Patients ≤59 kg: Withdraw weight based dose from a sealed bottle and place in a separate container for IV infusion to avoid inadvertent administration of the total volume from the commercially available container

            IV Administration

            Infuse through indwelling needle or soft catheter; take blood samples from contralateral arm

            Infuse over 30 min

            Storage

            Avoid excessive heat, store at 25 C

            Do not use solution previously frozen

            Previous
            Next

            Images

            Previous
            Next

            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
            Select State:
            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.