L-tryptophan (Herbs/Suppl)

Brand and Other Names:tryptophan
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Dosing & Uses

AdultPediatric

Depression

8-12 g/d PO divided QID/TID

Lower dosage effective in combination with other antidepressants

Administration

Take with low-protein, carbohydrate-rich meals or snacks

Safety and efficacy not established

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Interactions

Interaction Checker

and L-tryptophan

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Anorexia

            Dizziness

            Dry mouth

            Headache

            Nausea

            Sexual disinhibition

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            Warnings

            Contraindications

            Hypersensivity

            Cautions

            Bladder cancer

            Diabetes mellitus

            Achlorhydria/malabsorption

            Cataract formation

            Some bipolar pts are acutely sensitive & would not tolerate dosage >1-2 g/d

            Clinical worsening & suicide ideation may occur despite medication

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: avoid during breastfeeding

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: Converted to nicotinic acid & serotonin as well as incorporated into proteins

            Excretion: N/A

            Mechanism of Action

            Incr serotonin synthesis

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