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terbinafine topical (OTC)Brand and Other Names:Lamisil AT topical

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream/topical solution

  • 1%
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Tinea Pedis

Apply to affected area BID until significant clinical improvement (no more than 4 weeks)

Tinea Corporis & Cruris

Apply qDay x1 week (no more than 4 weeks)

Not FDA approved for peds

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Adverse Effects

1-10%

Burning

Contact dermatitis

Dryness

Exfoliation

Irritation

Pruritus

Rash

Irritation

Stinging

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Warnings

Contraindications

Hypersensitivity

Not for oral, intravaginal, ophthalmic use

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Pregnancy & Lactation

Pregnancy Category: B

Lactation: not safe for nursing infants

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Metabolism: liver

Excretion: urine

Mechanism of Action

Inhibits squalene epoxidase, reducing cell membrane ergosterol synthesis

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