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alcaftadine ophthalmic (Rx)Brand and Other Names:Lastacaft

 
 
 

Dosing & Uses

AdultPediatric

Dosing Form & Strengths

ophthalmic solution

  • 0.25%

Allergic Conjunctivitis

Indicated for prevention of itching associated with allergic conjunctivitis

Instill 1 gtt to each eye daily

Dosing Form & Strengths

ophthalmic solution

  • 0.25%

Allergic Conjunctivitis

Indicated for prevention of itching associated with allergic conjunctivitis

<2 years: Safety and efficacy not established

≥2 years: As adults, instill 1 gtt to each eye daily

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Adverse Effects

1-10%

Ocular

  • Irritation
  • Burning
  • Stinging
  • Redness
  • Pruritus
  • Eye discharge
  • Eye swelling
  • Erythema of eyelid
  • Eyelid edema

Nonocular

  • Nasopharyngitis
  • Headache
  • Influenza
  • Somnolence

Postmarketing reports

Lacrimation increased

Vision blurred

Hypersensitivity reactions including swelling of the face or allergic dermatitis

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Warnings

Contraindications

Hypersensitivity

Cautions

To minimize eye injury and contamination of dropper tip and solution, care should be taken not to touch eyelids or surrounding areas with dropper tip of bottle; keep bottle tightly closed when not in use

Keep bottle tightly closed when not in use

Do not use for contact lens–related irritation

Remove contact lenses before instillation

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Pregnancy & Lactation

Pregnancy Category: B

Lactation: Unknown whether distributed in breast milk, caution advised

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

H1-receptor antagonist; inhibits histamine release from mast cells, decreases chemotaxis, and inhibits eosinophil activation

Pharmacokinetics

Absorption: Minimal

Half-Life: 2 hr

Peak Plasma Time: 0.25 hr; active metabolite 1 hr

Peak Plasma Concentration: 60 pg/mL (levels fell below limit of quantification by 3 hr); active metabolite 3 ng/mL

Protein Bound: 39.2%; active metabolite 62.7%

Metabolism: Non-CYP450 cytosolic enzymes to active metabolite carboxylic acid

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Administration

Instructions

If more than 1 topical ophthalmic medicinal product is being used, each one should be administered at least 5 minutes apart

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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