Adjunctive Treatment for Cancer & HIV
1-4 mg IV/IM once/week
Possibly effective as adjunct when administered with didanosine in HIV
Insufficient Evidence to rate as adjunctive treatment for breast, gastric, prostate cancer. Preliminary evidence suggests improvement
Serious - Use Alternative
Significant - Monitor Closely
Chronic large dose of whole shiitake can cause dermatitis, eosinophilia
Pregnancy & Lactation
Pregnancy Category: N/A
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Potentiates NK cell, macrophage, T-helper cell function