flavocoxid/citrated zinc bisglycinate (Rx)

  • Print
Brand and Other Names:Limbrel

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

flavocoxid

capsule

  • 250mg
  • 500mg
more...

Osteoarthritis

Medical food product indicated for the clinical dietary management of the metabolic processes of osteoarthritis

250-500 mg PO q12hr

Administration

May take with or without food

Increased absorption if taken 1 hr before or after meals

Taking with food does not affect metabolism and may buffer effects of slight indigestion

Safety and efficacy not established

Next:

Interactions

Interaction Checker

and flavocoxid/citrated zinc bisglycinate

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 
            Previous
            Next:

            Adverse Effects

            Frequency Not Defined

            Nausea

            Diarrhea

            Flatulence

            Hypertension

            Psoriasis

            Jaundice

            Liver injury

            Fluid on the knee

            Occult stools

            Psoriasis

            Previous
            Next:

            Warnings

            Contraindications

            Hypersensitivity to any component of flavocoxid or to flavonoids; foods rich in flavonoid contents include colored fruits and vegetables, dark chocolate, tea (especially green tea), red wine, and Brazil nuts

            Cautions

            Borderline elevations (1.2-3x ULN) of 1 or more liver tests without other signs or symptoms occurred in controlled clinical trials in <10% of subjects; notable elevations of ALT and AST (approximately >3 to 5x ULN) occurred in controlled clinical trials in <2% of subjects

            Hypersensitivity pneumonitis (rare reports)

            Use caution in patients with history of GI disorders

            Use only under close supervision of a healthcare professional

            Previous
            Next:

            Pregnancy & Lactation

            Pregnancy Category: Not studied; not recommended

            Lactation: Unknown if excreted in breast milk; not recommended

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next:

            Pharmacology

            Mechanism of Action

            Flavocoxid: Blend of 2 flavonoids, Free-B-Ring flavonoids (eg, baicalin) and flavans (eg, catechin), from Scutellaria baicalensis and Acacia catechu respectively

            Reduces arachidonic acid (AA) metabolism by weakly inhibiting COX-1 and COX-2 enzymes, as well as the 5-lipoxygenase enzyme; restores and maintains balance of AA metabolites at approximately equal levels to maintain physiologic function in osteoarthritis

            Elicits strong antioxidant activity to limit oxidative conversion of AA to damaging fatty acid products

            Pharmacokinetics

            Bound primarily to albumin

            <10% metabolized via glucuronidation and sulfation by hepatic metabolism involving cytochrome P450 isoenzymes

            Onset of action: 1-2 hr

            Previous
            Next:

            Images

            Previous
            Next:

            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous