Dosing & Uses
Dosage Forms & Strengths
Medical food product indicated for the clinical dietary management of the metabolic processes of osteoarthritis
250-500 mg PO q12hr
May take with or without food
Increased absorption if taken 1 hr before or after meals
Taking with food does not affect metabolism and may buffer effects of slight indigestion
Safety and efficacy not established
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Fluid on the knee
Hypersensitivity to any component of flavocoxid or to flavonoids; foods rich in flavonoid contents include colored fruits and vegetables, dark chocolate, tea (especially green tea), red wine, and Brazil nuts
Borderline elevations (1.2-3x ULN) of 1 or more liver tests without other signs or symptoms occurred in controlled clinical trials in <10% of subjects; notable elevations of ALT and AST (approximately >3 to 5x ULN) occurred in controlled clinical trials in <2% of subjects
Hypersensitivity pneumonitis (rare reports)
Use caution in patients with history of GI disorders
Use only under close supervision of a healthcare professional
Pregnancy & Lactation
Pregnancy Category: Not studied; not recommended
Lactation: Unknown if excreted in breast milk; not recommended
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Flavocoxid: Blend of 2 flavonoids, Free-B-Ring flavonoids (eg, baicalin) and flavans (eg, catechin), from Scutellaria baicalensis and Acacia catechu respectively
Reduces arachidonic acid (AA) metabolism by weakly inhibiting COX-1 and COX-2 enzymes, as well as the 5-lipoxygenase enzyme; restores and maintains balance of AA metabolites at approximately equal levels to maintain physiologic function in osteoarthritis
Elicits strong antioxidant activity to limit oxidative conversion of AA to damaging fatty acid products
Bound primarily to albumin
<10% metabolized via glucuronidation and sulfation by hepatic metabolism involving cytochrome P450 isoenzymes
Onset of action: 1-2 hr
Adding plans allows you to compare formulary status to other drugs in the same class.
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Adding plans allows you to:
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
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Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.