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lindane (Rx)Brand and Other Names:

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

lotion/shampoo

  • 1%
more...

Scabies

Lotion: Apply thin layer and massage on skin on entire body except face; bathe and remove drug 8-12 hr after application

Head Lice or Crab Lice

Apply 1-2 oz of shampoo (not to exceed 2 oz) on dry hair; leave on 4 min, lather, rinse, remove nits with fine comb

One time application usually sufficient; may use other pediculicide in 1 wk if necessary

Other Indications & Uses

Pubic lice & ova; cream & lotion indicated for scabies ONLY if intolerant to or failed first-line Tx

Dosage Forms & Strengths

lotion/shampoo

  • 1%
more...

Scabies

Lotion: Apply thin layer and massage on skin on entire body except face; bathe and remove drug 8-12 hr after application

Head Lice or Crab Lice

Apply 1-2 oz of shampoo (not to exceed 2 oz) on dry hair; leave on 4 min, lather, rinse, remove nits with fine comb

One time application usually sufficient; may use other pediculicide in 1 wk if necessary

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Adverse Effects

Frequency Not Defined

Slight local irritation (including eczematous eruptions, rash, conjunctivitis)

Repeated application frequently causes contact dermatitis

CNS toxicity (seizures)

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Warnings

Black Box Warnings

Neurotoxicity, including seizures and death, has been reported with repeat or prolonged application, and rarely with single application.

Use with caution in those at risk for neurotoxicity including infants, children, elderly persons, those who weigh <50 kg, or those with a history of seizures. It is contraindicated in premature infants and in those with uncontrolled seizure disorders. Counseling the patient on proper use is required.

Contraindications

Premature neonates (<28 do) (increased absorption), uncontrolled seizure disorder, hypersensitivity, Norwegian (crusted) scabies, skin conditions that may incr systemic absorption

Retreatment

Cautions

Not first-line

Risk of serious neurotoxicity in children weighing <50 kg

HIV infection, history of head trauma or a prior seizure, CNS tumor, severe hepatic cirrhosis, excessive use of alcohol, abrupt withdrawal from alcohol or sedatives, concomitant use of medications known to lower seizure threshold

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: distributed in breast milk, do not nurse for 24 hr post-application (express milk & discard)

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
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Pharmacology

Absorption: slowly & incompletely absorbed through intact skin when applied topically

Metabolism: liver

Excretion: urine & feces

Mechanism of Action

Following absorption through the chitinous exoskeleton of arthropods, cyclic chlorinated hydrocarbons like lindane presumably stimulate the nervous system, resulting in seizures & death

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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