acetohydroxamic acid (Rx)

Brand and Other Names:Lithostat
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 250mg
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Chronic Urinary Tract Infection

Indicated for chronic UTS caused by urea-splitting organisms

Initial: 12 mg/kg/day PO divided q6 -8hr on empty stomach 

Maintenance: 250 mg PO q6-8hr; not to exceed 1.5 g/day

Renal Impairment

SCr 1.8-2.5 mg/dL [159-221 micromoles/L]: Dose q12hr; not to exceed 1 g/day

SCr >2.5 mg/dL [>221 micromoles/L]: Not recommended

Dosage Forms & Strengths

tablet

  • 250mg
more...

Chronic Urinary Tract Infection

Indicated for chronic UTS caused by urea-splitting organisms

Initial: 10 mg/kg/day PO divided q6-8hr on empty stomach; titrate to patient response 

Chronic Urinary Tract Infection

Indicated for chronic UTS caused by urea-splitting organisms

Initial: 12 mg/kg/day PO divided q6-8hr on empty stomach

Maintenance: 250 mg PO q6-8hr; not to exceed 1.5 g/day

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Interactions

Interaction Checker

and acetohydroxamic acid

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     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Mild headache; first 48 hours (30%)

            Anorexia (20-25%)

            Malaise (20-25%)

            Nausea (20-25%)

            Vomiting (20-25%)

            Anxiety (20%)

            Confused (20%)

            Depression (20%)

            Involuntary quivering (20%)

            Hemolytic anemia (15%)

            <1%

            Alopecia

            Blood clot

            Macular rash

            Phlebitis

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            Warnings

            Contraindications

            Hypersensitivity

            Pts. amenable to definitive surgery & antimicrobial agents, infection by non-urease producing organisms, urinary infections controlled by culture-specific antimicrobials, severe renal impairment (CrCl <20 mL/min &/or serum creatinine>2.5 mg/dL [221 umol/L]), inadequate contraception (females), pregnancy

            Cautions

            Always use with appropriate antimicrobial treatment

            Potential teratogen

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            Pregnancy & Lactation

            Pregnancy Category: X

            Lactation: excretion in breast milk unknown/not recommended

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Inhibits bacterial urease, decreasing ammonia production

            Does not acidify urine or have direct antibacterial effect

            Pharmacokinetics

            Absorption: Well-absorbed

            Peak Plasma Time: 15 min -1 hr

            Excretion: Urine (55% of oral dose unchanged)

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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