clotrimazole topical (Rx, OTC)

Brand and Other Names:Gyne Lotrimin, Lotrimin, more...Lotrimin AF, Mycelex topical
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream/ointment/topical solution

  • 1%
more...

Cutaneous Candidiasis/ Dermatophytosis

OTC products indicated for treatment of tinea pedis, tinea cruris, and tinea corporus

Prescription products indicated for Candida albicans and tinea versicolor, in addition to OTC product indications

Apply to affected area q12hr

See also combo with betamethasone (Lotriderm/Lotrisone)

Dosage Forms & Strengths

cream/ointment/topical solution

  • 1%
more...

Tinea Corporis/Tinea Pedis

Apply to affected area q12hr for 4 weeks

Tinea Cruris

>2 years: Apply to affected area q12hr for 2 weeks

Candidiasis

Gently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks

Tinea Versicolor

Gently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks

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Adverse Effects

Frequency Not Defined

Blistering

Erythema

Edema

Pruritus

Burning

Stinging

Peeling

Urticaria

Skin fissures

General irritation of the skin

Elevated serum AST (SGOT) concentrations (15%)

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Warnings

Contraindications

Hypersensitivity to clotrimazole

Cautions

Avoid contact with eyes

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Pregnancy & Lactation

Pregnancy category B during 2nd and 3rd trimester; safety in 1st trimester not established

Lactation: Excretion in milk unknown; use with caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Antifungal activity

Alters cell membrane permeability, apparently by binding with phospholipids in the fungal cell membrane, causing essential intracellular elements to leak

Absorption

Minimal through skin

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Images

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
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  • Compare formulary status to other drugs in the same class.
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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