fluoride (Rx)Brand and Other Names:Luride, Karidium, more...Fluoritab, Pediaflor, sodium fluoride

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

Strength expressed as fluoride ion

tablet

  • 0.25mg
  • 0.5mg
  • 1mg

oral liquid

  • 0.125mg/drop

tablet, chewable

  • 0.25mg
  • 0.5mg
  • 1mg

lozenge

  • 1mg
more...

Dental Caries Prevention

Intake typically achieved from drinking tap water (community levels vary)

Males adequate intake: 4 mg/day

Females adequate intake: 3 mg/day

Upper limit:10 mg/day

Otosclerosis (Off-label)

20-120 mg sodium fluoride/day divided three times daily PO, usually 20-40 mg/day

Osteoporosis (Off-label)

30-100 mg sodium fluoride /day PO

Dosage Forms & Strengths

Strength expressed as fluoride ion

tablet

  • 0.25mg
  • 0.5mg
  • 1mg

oral liquid

  • 0.125mg/drop

tablet, chewable

  • 0.25mg
  • 0.5mg
  • 1mg

lozenge

  • 1mg
more...

Adequate Intake

Dosing depends on local fluoride content of water supply

Water <0.3 ppm F ion

  • Birth - 6 months: None
  • 6 months - 3 years: 0.25 mg PO qDay
  • 3-6 years: 0.5 mg PO qDay
  • 6-16 years: 1 mg PO qDay

Water 0.3-0.6 ppm F ion

  • Birth - 6 months: None
  • 6 months - 3 years: None
  • 3-6 years: 0.25 mg PO qDay
  • 6-16 years: 0.5 mg PO qDay

Water >0.6 ppm F ion

  • All ages: Supplementation not required

Dose Consideration

Potential toxic dose <6 years: 8 mg/kg

1 ppm = 1 mg fluoride ion

2.2 mg sodium fluoride contains 1 mg fluoride ion

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Interactions

Interaction Checker

fluoride and

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     activity indicator 
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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Nausea

            Rash

            Vomiting

            Discoloration of teeth

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            Warnings

            Contraindications

            Hypersensitivity to fluoride, tartrazine, components of the formulation

            Fluoride content in drinking water >0.7ppm

            Low sodium or sodium-free diets

            1 mg tab in < 3 years of age or when drinking water >0.3 ppm

            1 mg/5 mL rinse in children <6 years of age

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            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: Safe when used in doses below 10 mg per day of elemental fluoride; safe in quantities found in toothpastes, mouth rinses, and fluoride dental treatments

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Increases resistance to acid dissolution of the tooth

            Promotes remineralization of decalcified enamel

            In dental plaque inhibits cariogenic microbial process

            Pharmacokinetics

            Absorption: Rapid and complete; absorption delayed by other soluble fluoride salts, magnesium, calcium, or iron

            Excretion: Urine and feces

            Distribution: 50% of fluoride (deposited in teeth and bone after ingestion); topical application works on enamel and plaque superficially

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            Formulary

            FormularyPatient Discounts

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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